Drugs

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Drugs

• Emezie Okorafor
• Senior- Course 10 Chemical Engineering

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Overview

• Drugs and their patents
• Importance of drug patents
• Predicting the market
• Future Work
• Heart
• Conclusion

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Drugs Who owns what?

• Rapamycin
• Paclitaxel
• Everolimus
• ABT-578

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Rapamycin
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Rapamycin

• Wyeth possesses rights to patent
• Discovered by Sir Roy Calne
• Licensed to Johnson Johnson CYPHER
• Novartis attempt

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Paclitaxel
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Paclitaxel

• Double-Double license
  NeoRx gt Angiotech gt Boston Sci./Cook
• Boston Scientific TAXUS
• Other companies interested in paclitaxel
  derivatives Bristol Myers
• NaBio Therapeutics

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Everolimus
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Everolimus
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Everolimus

• Novartis possesses rights to patent
• rapamycin derivative
• Licensed to Guidant VISION
• Guidants rough history with stents actinomycin
  D paclitaxel

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ABT-578
Licensed to
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ABT-578

• Abbott possesses rights to patent
• yet ANOTHER rapamycin derivative
• Licensed to Medtronic ENDEAVOR
• Mutual agreement risky?

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Respect the Drug Patent !!!

• A vital component of the entire
  drug-eluting stent industry
• They can make or break a company
• Dont experiment with drug-patents
• They are NO JOKE.

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Drug Companies

• Estimated revenue 2004 56 million
• Total revenue in 2002 7 million

• Wyeth/Novartis
• Bristol Myers/NaPro Therapeutics

Numbers stolen shamelessly from Minna Oh
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Stent Companies

• Profit 1,750 per stent
• Bad things happen to those who do not respect
  drug patents Guidant
• Both attempts to combat the drug patentFAILED.

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The moral of the story

• Stent Sales/Total Sales Guidant
  10 Johnson Johnson 5 Medtronic
  2 Boston Scientific 43
• The violation of a drug patent can wreck you
  RESPECT!

Numbers pillaged from Jeffery Su
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Who has the best patent?

• Can you predict which drug company will dominate
  the market based on the drug patent they hold?

• Nope. Not really.

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Future Prospects

• Derivatives how do these guys get away with
  this???
• Why are some derivative patents accepted, while
  others are ruled invalid?
• NeoRx gt Angiotech gt Boston Sci./Cook

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Drugs really got a hold of me

• Drug patents Good or Bad?
• Good Encourage innovation and progress
• Bad Discourage innovation and progress

Lyrics borrowed from Eminem
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Conclusion

• Rapamycin Wyeth gt Johnson Johnson
• Paclitaxel Angiotech gt Boston Sci./Cook
• Everolimus Novartis gt Guidant
• ABT-578 Abbott gt Medtronic

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