The Indiana University Cyclotron Facility (IUCF) is a multidisciplinary laboratory performing research and development in the areas of accelerator physics, nuclear physics, materials science, biophysics and biomedical applications. Research and

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Indiana University Cyclotron Facility
RESEARCH and Development at IUCF
LIST OF SERVICES
OVERVIEW

• Advanced Electron-Photon Facility (ALPHA) laser
  synchrotron X-ray source will enable the
• structural analysis of hydrated
  macromolecules when construction is completed in
  late 2009
• Instrumentation Development throughout all scales
  from nanotechnology to green field
  construction is performed in collaboration with
  researchers from within IU, nationally and
  internationally
• Low Energy Neutron Source (LENS) university-based
  neutron scattering platform
• Small Angle Neutron Scattering (SANS) enables
  materials science and structural biology
  investigations
• Spin Echo Scattering Angle Measurement
  (SESAME) will enable structural analysis of
  highly-ordered
• biological materials upon completion of
  construction in February, 2009
• Neutron Radiation Effects Program (NREP) provides
  low energy neutron beam for
• technology, research and development
• Particle Therapy Technology Development including
  beam delivery and diagnostic devices
• Patient Specific Device Manufacture including
  apertures and missing tissue compensators for
• proton therapy treatments
• Radiation Effects Research Program (RERP)
  provides proton radiation for technology,
• research and development
• Solar Proton Radiobiology Institute for the
  multidisciplinary investigation of coincident
• physiological effects of human
  extraterrestrial travel within the solar system

The Indiana University Cyclotron Facility (IUCF)
is a multidisciplinary laboratory performing
research and development in the areas of
accelerator physics, nuclear physics, materials
science, biophysics and biomedical applications.
Research and educational experiences are
available to high school through post-doctoral
students. The facility is supported by Indiana
University, state and federal grants, and user
fees and contracts. The laboratory is staffed by
approximately 130 highly trained scientific,
technical, and administrative staff members and
serves approximately 60 on-site graduate
students, postdoctoral research fellows and
faculty members. In addition, research activities
are carried out by scientists and students from
around the world through collaborations,
partnerships and contractual service agreements.
IUCF operates one of 5 proton therapy facilities
in the US.
Age-Related Macular Degeneration (AMD) Phase 3
Clinical Trial T Ciulla3, R Danis3, V
Malinovski8, S Soni8, C Bloch7, S Klein7, NO Pugh9
Retreatments with Proton Therapy A Thornton2,3
Cases 24 Median
OS 1.7 yrs Local failure
28 Complications
3 Case mix 30 Base of Skull 20
Head Neck 10 Vertebral column 25 Brain 15
Rectal/GI
A
Vision evaluations taken at 6 month intervals
disclosed unexpected stability for the control
group.
RESOURCES
B
Engineering drawing of the eye treatment beam
line.
A Eyeplan treatment plan for AMD B overlay of
eye phantom treatment verification film.

• The Midwest Proton Radiotherapy Institute (MPRI)
  is a free-standing proton radiation therapy
  clinic located at IUCF and associated with the
  Indiana University School of Medicine (IUSM). The
  clinic includes a CT suite, reception area, three
  exam rooms, immobilization prep room, recovery
  room and linac suite in addition to the three
  treatment rooms housing the Proton Therapy System
  (PTS). The PTS was designed, fabricated and
  installed at the Indiana University Cyclotron
  Facility. It is the most technologically advanced
  proton radiation therapy machine in the US and
  occupies approximately one sixth of the ground
  floor of IUCF.

Patients 37 Mean age 71.2 Vision at
enrollment Dose 16Gy 20/40
20/400 Fractions 2 Follow up 24
months Case mix 32 classic, 11 occult, 57
mixed.
Vic Malinovsky and Ron Danis critique the newly
constructed eye treatment beam line.
QUALITY CONTROL AND ASSURANCES
Comparison of Commissioning Results for Passive
Scattering and Scanning Proton Beam Systems at
MPRI M. Wolanski2,3, C. Allgower2,3, L.
Coutinho2,3, J.B. Farr6, M. Fitzek2,3, R.
Jesseph2,5, A. Mascia2,5, A. Thornton2,3, V.
Anferov7, D. Nichiporov7
The Indiana University Cyclotron Facility (IUCF)
operates the Proton Therapy System (PTS) and
manufactures medical devices under 510K approval
from the FDA. This approval is based upon the
IUCF Quality System Plan (QSP) that defines the
good manufacturing practices established at
IUCF. The QSP is described by 16 standard
operating procedures (SOP) Management Review
Committee Tier I SSC Configuration
Baseline Standard Operating Procedure
Requirements Design Controls Document
Controls Control of Non-Conformities Corrective
and Preventive Action Purchasing
Controls Inspection and Test Controls Process
Controls Quality Records Controls Audit
Controls Impact Analysis Board QSP Training
Standards FDA Reporting Servicing Controls CAPA
Corrective and Preventive Action IRB Impact
Analysis Board MRC Management Review
Committee NCR - Nonconformance Report QSP
Quality System Plan SSC - Structures, Systems and
Components
Vertebral column proton radiation treatment plan
for recurrent disease following conformal x-ray
therapy.
The Proton Therapy System (PTS) consists of 7
subsystems designed, fabricated and installed at
IUCF/MPRI the beam production system, the beam
handling system, the beam delivery system, the
dose delivery system, the radiation safety
system, the patient positioning system and the
integrated treatment room control system.
Representative Spread Out Bragg Peaks (SOBP)
generated by the active scanning nozzle at MPRI.
Maximum energy range was 208MeV. Data were
collected using the IUCF MLIC and the plan was
generated by XiO for protons.

• The proton radiation research and development
  platforms, part of the Radiation Effects Research
  Program (RERP), share proton beam from the PTS
  cyclotron. Beam is delivered to each of the three
  treatment rooms and the two RERP stations by a
  fast switching system that provides protons to
  each of two research stations. Available at these
  stations are fluxes between 102 and 1011
  protons/second/cm2 and momentum selected beam
  energies between 205MeV and 52MeV for
  translational physics, engineering, and biology.
  The unique IUCF fast switching kicker magnet
  system make both beam sharing and beam gating
  possible at MPRI and RERP.

Schematic diagram of the scanning beam nozzle
shows the binary carbon plate range shifter and
compact x-y magnet unique to the IUCF design.
The scanning nozzle is mounted in the IUCF PTS
incorporating a 360o isocentric gantry and
robotic patient positioner..
Myocardial Revascularization Following Radiation
Injury K March3, M Miller3, S Klein7
IUCF developed fast organ-motion beam gating to
support investigation of myocardial
revascularization. The small animal CT image
below shows the calcified scarring produced by
radiation damage. Beam entered from the apex.
Schematic of the kicker magnet engineering shows
how the beam path is switched from one beam line
to another in 9 nsec.

• The Low Energy Neutron Source (LENS) is a novel,
  university-based pulsed neutron source that
  utilizes a 13MeV linear accelerator to deliver
  proton beam to a beryllium target by either
  short or long pulses. A highly optimized
  liquid methane moderator produces cold and very
  cold neutrons for use by a suite of neutron
  scattering instruments and development
  facilities. These facilities include the Small
  Angle Scattering Source (SANS) and SESAME, a
  polarized neutron source that will enable
  small, complex sample biophysics. The

CONTACT INFORMATION
Neutrons interact with organic nuclei such as C
and H. A neutron radiograph discloses rubber
gaskets and plastic components in a gas pump .
Neutron scattering is opti-mized for biological
tissues materials.
Neutron Radiation Effects Program (NREP)
station is located just beyond the first LENS
moderator. It generates a neutron spectrum with a
5MeV endpoint. Directly adjacent to the RERP data
collection area and across the hall from LENS is
a 990 sq ft wet lab including a
ventilation-isolated tissue culture (TC) room to
support materials science and biological
radiation experiments.

• Indiana University Cyclotron Facility
• http//www.iucf.indiana.edu
• 2401 Milo B. Sampson Ln.
• Bloomington, IN 47408
• James A. Musser, Interim Director
• Phone [phone]
• Fax [phone]

• Midwest Proton Radiotherapy Institute
• http//www.mpri.org
• 2425 Milo B. Sampson LaneBloomington, IN 47408
• Phone [phone]
• Fax [phone]
• Email mpri_at_mpri.org

Proton Treatment Planning of Patients with
Implanted Metallic Hardware A ORyan-Blair2,3,5,
A Thornton2,3, AN Schreuder5, Wen Hsi4, M
Fitzek2,3
Measurement of intra-fractional organ motion
effects on simulated lung tumors Comparison
between passively scattered proton beam and a
scanning proton beam delivery systems Li Zhao1,
2, G Sandison1, Jonathan Farr6, Robert Zamenhof
2,3, and M Fitzek 2, 3

• The Advanced Photon-Electron Facility (APLHA)
  will serve the global research community in a
  wide variety

NREP station thermal modulator within LENS.
areas upon completion of construction in 2009.
X-ray and VUV sources are of great importance for
probing the structure and properties of
biological and condensed matter systems. ALPHA
will produce X-ray brilliance a factor of 10,000
times greater than the standard X-ray rotating
anode facilitating macromolecular biophysics
investigations, including structural analysis of
hydrated biological macromolecules.
1) Purdue UniversitySchool of Health Sciences,W
Lafayette, Indiana 2) Midwest Proton Radiotherapy
Institute, Bloomington, Indiana 3) Indiana
University School of Medicine, Indianapolis,
Indiana 4) University of Florida, Jacksonville,
Florida 5) ProCure Treatment Centers,
Bloomington, Indiana 6) West German Proton
Therapy Centre, Essen, Germany 7) Indiana
University Cyclotron Facility, Bloomington,
Indiana 8) School of Optometry, Bloomington,
Indiana University 9) Methodist Hospital,
Indianapolis, Indiana
ALPHA electron accelerator component of the high
brilliance X-ray source. This research platform
is being developed in collaboration with the
CRANE Naval Service Warfare Center for
multidisciplinary applications.
The green kicker magnet during PTS installation.
This magnet enables beam gating, and beam sharing.