Metallic Biomaterials

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Metallic Biomaterials
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Metals Are Crystalline
Body-Centered Cubic
The body-centered cubic (bcc) crystal structure
(a) hard-ball model (b) unit cell and (c)
single crystal with many unit cells. Source W.
G. Moffatt, et al., The Structure and Properties
of Materials, Vol. 1, John Wiley Sons, 1976.
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Metal Bonding

• The electrons in metals are mobile and surround a
  core of cations. This gives rise to their high
  electrical conductivity.

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Crystals and Grain Formation
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Product Manufacture

• There are 4 main methods of metal product
  manufacture
• machining
• melt casting
• forming
• hot isostatic pressing (sintering)

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Influence of Manufacturing Process
Casting Defect
Polished-etched view of a cast ASTM F75 femoral
hip stem. Note dendrites and large grains
In vivo fracture initiated from an inclusion
formed during the casting process
From H. Alexander et al., Chapter 2,
Biomaterials Science, BD Ratner et al., Academic
Press, 1996.
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Metallic Biomaterials

• There are 3 main groups of metals used as
  biomaterials
• stainless steels
• Co-based alloys
• titanium-based alloys

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Design Considerations

• typically want to match mechanical properties of
  tissue with mechanical properties of metal
• have to consider how the metal may fail in vivo
• corrosion
• wear
• fatigue
• need to consider cost

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Mechanical Properties
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Corrosion

• The extra-cellular environment is a chemically
  aggressive space. Metallic biomaterials are good
  conductors in an electrolyte solution, leading to
  galvanic corrosion.

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Corrosion
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Mechanisms of Corrosion

• Crevice Corrosion
• Pitting Corrosion
• Intergranular Corrosion

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Mechanisms of Corrosion

• Fretting Corrosion Stress Corrosion Cracking

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Mechanisms of Corrosion
Contribution of biological environment
From S.H. Teoh, International Journal of
Fatigue 22 (2000) 825837
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Wear

• The effects of wear are most predominant in joint
  prostheses.
• There are two types of wear
• Interfacial Wear Occurs when bearing surfaces
  come into contact with no lubricant fluid
  between them.
• Fatigue Wear Progressive failure due to
  application of cyclical stresses.

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Fatigue