Acute complications of DKA and HHS

1
Acute complications of DKA and HHS

• Clerk ???
• ???????

2
Introduction

• Most acute and severe complications of DM
• Occur in both types of DM( type 1 and 2)
• Mortality rate in HHS is raging form 1050,
  depending on underlying disease.
• Mortality rate in DKA is less than 5.

3
Pathogenesis

• Insulin decrease ?
• Counter-regulatory hormone increase Glucagon,
  catecholamines, cortisol growth hormone ?
• Hepatic glucose production increase ?
• ?glucose utilization of peripheral tissue
• gt glycosuria, osmotic diuresis dehydra-tion

4
Pathogenesis

• In DKA lead to the release of free fatty acid
  into circulation from fatty tissue.
• Unrestrained hepatic fatty acid oxidation to
  ketone bodies (