Prostate Cancer Vaccines and Therapeutic Antibodies: Pipeline, 2011

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Aarkstore.com Prostate Cancer Vaccines and
Therapeutic Antibodies Pipeline, 2011
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Summary

• The prostate cancer immunotherapy pipeline is
  showing rapid development. Currently, there are
  30 candidates in the pipeline (16 vaccines and 14
  therapeutic antibodies), and one prostate cancer
  vaccine (Provenge) has recently been approved by
  the FDA. First-line treatments for prostate
  cancer are largely based on anti-androgen drugs,
  or pituitary down-regulators. Other treatments
  include surgery, radiotherapy and chemotherapy.
  Resistance is commonly seen in the case of
  androgen-targeting drugs. Other therapies such as
  surgery and radiotherapy may be effective, but
  present increased risk. These treatment
  limitations have prompted efforts to develop
  safer, targeted therapies. In April 2010,
  Dendreon Inc. received FDA approval for its
  vaccine, Provenge an autologous cellular
  immunotherapy developed for metastatic prostate
  cancer. This vaccine is based on the use of
  patients own peripheral blood mononuclear cells,
  following prior treatment with a Prostate Acid
  Phosphatase/Granulocyte-Macrophage
  Colony-Stimulating Factor (PAP/GM-CSF) fusion
  protein. PAP is a commonly expressed prostate
  cancer antigen. The development of new
  candidate vaccines and therapeutic antibodies to
  target prostate cancer, is showing rapid
  progress. There are 30 candidates in the pipeline
  (16 prostate cancer vaccines and 14 prostate
  cancer-targeting antibodies)

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Table of Contents

• Report ContentsExecutive SummaryChapter 1
  Background p.7 1. Prostate Cancer1.1
  Statistics1.2 Diagnosis1.3 Staging1.4 Current
  Treatments1.5 This ReportChapter 2 Prostate
  Cancer Immunotherapy Strategies p.12 2.1
  Vaccines AntibodiesChapter 3 Approved Vaccine
  p.18 Chapter 4 Phase III Vaccines and
  Antibodies p.23

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