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Skin Histology

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Chapter 5 Skin Histology Epidermis J.F. Thompson, Ph.D. The Architecture of the Skin 2 Principal portions Epidermis - epithelium Dermis areolar and dense ... – PowerPoint PPT presentation

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Title: Skin Histology


1
Chapter 5
  • Skin Histology
  • Epidermis
  • J.F. Thompson, Ph.D.

2
The Architecture of the Skin
  • 2 Principal portions
  • Epidermis - epithelium
  • Dermis areolar and dense irregular fibrous
    connective tissue
  • Hypodermis
  • beneath the dermis
  • the subcutaneous layer next to
  • adipose layer or
  • muscle or
  • bone

3
The Epidermis
  • Stratified Squamous Epithelium
  • 4 cell types
  • Keratinocytes - 90
  • filled with keratin (protein)
  • waterproof barrier
  • Melanocytes - 8
  • produce melanin (pigment)
  • pass melanin to keratinocytes
  • Langerhans cells
  • phagocytes (from immune system)
  • easily damaged by UV light
  • Merkel cells
  • in deepest layer of hairless skin
  • sensory transduction - touch

4
Keratinocytes and Melanocytes
5
Merkel Cells
6
Langerhans Cells
7
Epidermal Cell Layers
  • Stratum basale
  • A single layer of cuboidal/columnar cells
  • Stem cells, melanocytes, Merkel cells
  • Stem cells ? keratinocytes, mitosis pushes the
    other layers to the top
  • Stratum spinosum
  • 8 to 10 layers of closely packed cells
  • Cell junctions - spot desmosomes
  • Langerhans cells

8
Epidermal Cell Layers
  • Stratum granulosum
  • 3-5 layers of flattened, with keratohyaline
    granules
  • beginning breakdown of nucleus, cell death
    initiated
  • Stratum lucidum
  • only in thick skin (palms, feet)
  • 3-5 layers of clear, flat dead cells with keratin
  • Stratum corneum
  • 20-30 layers of flattened, dead, keratin-filled
    cells
  • continuously shed and replaced
  • 2-4 weeks for each cell to form and to move from
    the stratum basale to the surface

9
Thin Skin
10
Thin Skin
  • Stratum Corneum
  • Stratum Granulosum
  • Stratum Spinosum
  • Stratum Basale

11
Thick Skin
12
End Ch 5
  • Skin Histology
  • Epidermis
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