SICKLE CELL ANEMIA

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SICKLE CELL ANEMIA

• BYJOEL SERRATA, EUNICE ASARE AND
  ARELI VELIZ.
• MENTOR DR.
  BRENNAN
• BRONX COMMUNITY
  COLLEGE
• CHEMISTRY
  DEPARTMENT

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DEFINITIONS

• SNP single nucleotide polymorphisms
• HBB Hemoglobin Beta Gene.
• Ulcer A sore cut cause by inflammation,
  disease, or infection.

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INTRODUCTION

• Sickle Cell Anemia is a hereditary disease
  which is cause by a disorder in the blood, a
  mutation in the Hemoglobin Beta Gene which can be
  found in the chromosome 11. This disease causes
  the body to make abnormally shapes red blood
  cells. A normal red blood cell is shaped as a
  round donut while the abnormal red blood cell
  has a C form.

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INTRODUCTION CONT

• Hemoglobin Beta Gene (HBB) also known as Beta
  Globin is a protein that resides in the red blood
  cells. The HBB is 146 amino acids long and its
  molecular weight is 15,867 Daltons. The molecules
  of the hemoglobin are responsible to carry oxygen
  through the body.
• The HBB is found in part 15.5 of the chromosome
  11.

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PROTEIN STRUCTURE

• a)
  b)

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ORIGIN

• The origin sickle cell anemia is thought to be
  originated from Africa and India, and then
  started spreading as people move and mated.

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RISK FACTORS

• A risk factor is what increases the chance of
  getting a disease or condition.
• The risk of having sickle cell anemia is that
  you're risk of dying of strokes and heart attacks
  dramatically increase.

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STATISTICS

• Statistic show that most of the people that have
  the sickle cell anemia are mostly African
  Americans and other minority.

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MEDICATIONS AND TREATMENTS
Hydroxyurea Treatment its a
chemical compound that is use as medication. For
sickle cell disease come in capsule form and its
administered once a day. Antibiotics
(penicillin) for children/helps prevent
infection. Bone Marrow Transplant of the bone
marrow to relieve pain.
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FUTURE GOALS

• The future goals are
• Create a new drug that can cure sickle cell
  anemia.
• Reverse the mutation or alter the biological
  function of proteins using SNP.

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ACKNOWLEDGEMENTS

• DR.BRENNAN
• SAT BATTACHARYA
• HARLEM CHILDREN SOCIETY

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REFERENCES

• C\Documents and Settings\me815-09\Desktop\SCA_Cau
  ses.html
• www.prism.gatech.edu/gh19/b1510/protsynt.htm
• www.mercksource.com/pp/us/cns
• www.sicklecelldisease-il.../sections/what/how.html
  
• http//www.ornl.gov/sci/techresources/Human_Genome
  /posters/chromosome/hbb.shtml
• http//healthgate.partners.org/browsing/Content.as
  p?fileName20158.xmltitleRiskFactorsforSickle
  CellDisease
• http//kidshealth.org/teen/diseases_conditions/blo
  od/sickle_cell_anemia.html
• http//sickle.bwh.harvard.edu/hemoglobin.html