Title: Take the following case. You are in a city in which the plague is raging. You, as a doctor, have a drug that you could use to combat the plague. However, you must test it on somebody. The commander, or let us say the mayor of the city, comes to you and
1- Take the following case. You are in a city in
which the plague is raging. You, as a doctor,
have a drug that you could use to combat the
plague. However, you must test it on somebody.
The commander, or let us say the mayor of the
city, comes to you and says, Here is a criminal
condemned to death. Save us by carrying out the
experiment on this man. Would you refuse to do
so, or would you do it?
2The Medical Ethos, Nazi Medicine, and the
Nuremberg Code
3Objective
- Progression of ideas and theories into policies
and then into practice can result in grave
consequences for medicine and humankind
4The Medical Ethos
- Composed of interlocking set of views about the
patient, the physician, and the medical
enterprise - Historical core values of medicine compassion,
healing, relief of suffering - Physicians role centered on healing and
alleviation - Special worth endowed upon the sick
- Medicine is compassionate and apolitical
5The Medical Ethos
- Long held view that the ethos was immutable and
that its values were stable despite individual
and cultural variation - Immune to social, political, and economic
pressures
6Hippocratic Oath
- Primum non nocere first, do no harm
- Focus on the individuals suffering
- Responsibilities of physician are not stratified
on the basis of a hierarchy of worth or on social
priorities of the state
7Social Darwinism
- 1859, Charles Darwins Origin of Species
published - Application of principles of natural selection to
human populations - Improvement of population through selective
cultivation
8Social Darwinism
- Social Darwinists stressed that the integrity
of populations was threatened because medicine
began to destroy the natural struggle for
existence - Shift in social balance
- The poor, misfits, and the genetically feeble
were overwhelming the talented, able, and
genetically strong
9Eugenics
- 1883, Francis Galton
- Eugenics the good birth
- Aimed at enhancing the quality of populations by
modification of natural selection through
selective breeding - Programs in the United States, Britain, and
Germany
10Racial Hygiene
- 1894, Alfred Ploetz
- If the fit were to be primary survivors,
counter-selective forces should be avoided,
including medical care for the weak, because this
promoted reproduction among them - Hierarchy of human worth
- subhuman, life without value, useless
eaters, useless life, ballast
11Racial Hygiene
- Movement included physicians, industrialists,
academics, politicians - Expanded rapidly
- Became a respectable part of German biomedical
science
12Consequences
- Concerted shift from the development and care of
the individual to the welfare of society as a
whole - Physicians were encouraged to move from doctoring
the individual to doctoring the nation
13United States
- Sterilization laws in the U.S.
- Resulted in the involuntary sterilization of
60,000 persons - Upheld by the Supreme Court in Buck v. Bell, 1924
- It is better for all the world, if instead of
waiting to execute degenerate offspring for
crime, or to let them starve for their
imbecility, society can prevent those who are
manifestly unfit from continuing their kind
Justice Oliver Wendell Holmes - Three generations of imbeciles are enough
- Racial segregation
14How Could this Happen? Historical Context
- Complicity of the German biomedical enterprise
needs to be examined in historical context - Expanding role of science to solve problems
- Industrialization and urbanization
- Poverty, crime, spread of infectious disease (TB,
syphilis, etc), expanding rise in mental illness - Social, economic, political upheaval of post-WWI
Germany, including the loss of millions of young,
fit Germans during the war.
15Medicine and Dictatorship
- Science under dictatorship becomes subordinate
to the guiding philosophy of the dictatorship -
Leo Alexander, M.D. - Rational utility replaces moral, ethical, and
religious values - Medical science becomes an instrument of
political power - Planning, initiation, administration, and
operation of state policies and programs
16Nazi Medicine
- National state must see to it that only the
healthy beget children by modern medical
needs. Adolf Hitler, Mein Kampf - Hitler asked that the German medical profession
move into the forefront of the race question - Racial hygiene was to be the task of the German
physician
17Nazi Public Health
- Nazi director of public health, Dr. Arthur Guett,
in The Structure of Public Health in the Third
Reich, 1935 - It is the supreme duty of a national state to
grant life and livelihood only to the healthy and
hereditarily sound portion of the people in order
to secure the maintenance of a hereditarily sound
and racially pure folk for all eternity. The life
of the individual has meaning only in light of
that ultimate aim, that is, in the light of his
meaning to his family and to his national state
18The German Medical Establishment
- Accepted, supported, and were instrumental in the
application of racial hygiene policies - Physicians adjusted to and accepted a new
hierarchy of human worth that devalued the
infirmed, the disabled, the genetically blighted - Embraced belief that to heal the nation was
incomparably more important than curing
individuals - Racial hygiene accepted as massive public health
measure as dictated by the state
19Physicians in the Nazi Party
- 6 of physicians belonged to the National
Socialist party prior to Hitlers coming to power - By late 1933, almost half of all physicians
belonged to the Nazi Party - 26 belonged to the SA
- 7 belonged to the SS
20Nazi Medicine
- Turned away from the sick and useless and
focused on a healthy state - Campaign of propaganda and dehumanization
- Focused on disease prevention and education
- Powerful and effective public health programs
- Anti-smoking
- Cancer prevention
- Nutrition
- Exercise
21Implementation
- Rise of Nazi power
- Political and judicial will of the state
- Willing medical establishment
- Policies
- Nuremberg laws
- Sterilization laws
- Euthanasia
22The Nuremberg Laws
- Excluded Jews from citizenship and prevented
marriage or sexual relations between Jews and
non-Jews - Marital health laws required couples to submit to
medical examination prior to marriage to prevent
racial pollution
23Sterilization Laws
- 1933 Sterilization Law Law for the Prevention of
Hereditarily Diseased Descendants - Allowed involuntary sterilization of anyone
suffering from disease thought to be genetically
determined - Feeble-mindedness, manic-depression,
schizophrenia, malformation, deafness, blindness,
epilepsy, alcoholism
24Sterilization Laws
- Hereditary health courts (1 lawyer, 2 physicians)
- Physicians required to
- Undergo training in genetic pathology
- Register every case of genetic illness known to
them - Fill sterilization quotas (50,000 annually)
25Sterilization Consequences
- Up to 400,000 (more than 1 of population)
sterilized
26Euthanasia
- September 1939
- Physicians to grant mercy death to patients
judged incurably sick by medical examination
27Euthanasia
- All state institutions required to report on all
patients who had been ill more than 5 years and
who were unable to work - Filled out questionnaires giving name, race,
nationality, marital status - Decision regarding who is euthanized was based on
these questionnaires - Euthanasia became part of normal hospital routine
28Nazi Human Experimentation
- Two types of experiments/motivations
- 1. Scientific pursuits designed to yield
information applicable to military and political
goals - 2. Advance personal goals/agendas
- Political
- Academic
29The Nuremberg Doctors Trial
- United States of America v. Karl Brandt et al
- Oct 1946 - July 1947
- 23 defendants (20 physicians, 3 assistants)
- The defendants in this case are charged with
murders, tortures, and other atrocities committed
in the name of medical science.
30Human Experimentation
- High-altitude Experiments
- individuals subjected to low-pressures to
simulate atmospheric conditions at high altitudes
(up to 68-thousand feet) - test the limits of human endurance at extremely
high altitudes with and without oxygen
31Human Experimentation
- Freezing Experiments
- victims placed in tank of ice water or kept naked
outdoors - investigated how to treat people who had been
chilled or frozen by testing different methods of
re-warming
32Human Experimentation
- Malaria Experiments
- victims infected by mosquitoes or injected with
extract of mucous glands of mosquitoes - Mustard Gas Experiments
- wounds deliberately inflicted on victims and then
infected with poisonous gas in search of
effective treatment for burns caused by mustard
gas - Sulfanilamide Experiments
- wounds infected with streptococcus, gas gangrene,
and tetanus, then wood shavings and ground glass
forced into wounds to test if sulfa drugs could
improve survival
33Human Experimentation
- Bone, Muscle, Nerve Regeneration, and Bone
Transplantation Experiments - section of bones, muscles, and nerves (including
whole limbs) removed from victims and
transplanted to other victims - Sea Water Experiments
- victims ingested salt water
- purpose was to develop method of making sea water
drinkable through desalination
34Human Experimentation
- Epidemic Jaundice Experiments
- subjects injected with epidemic jaundice
(hepatitis) - Sterilization Experiments
- victims sterilized by x-ray, surgery, and drugs
- goal was to develop cheap and quick sterilization
methods (surgical sterilization was too expensive
and slow) - Spotted Fever (typhus) Experiments
- victims injected with typhus to test various
vaccines
35Human Experimentation
- Poison Experiments
- victims deliberately poisoned to time how fast
death occurred and determine how much pain and
agony various poisons caused - Incendiary Bomb Experiments
- victims burned with phosphorous to then determine
the utility of ointments and liquid therapies - Jewish Skeleton Collection
- 112 Jews were murdered to complete a skeleton
collection for the Reich University at
Strasbourg, France
36Recurrent Themes of Nazi Medicine
- Devaluation and dehumanization of certain
segments of society - Medicalizing of social and political problems
- Consequences of refusal
- Bureaucratization of medical role
- Lack of concern for medical ethics and human
rights - Relationship between science and ideology
37The Nuremberg Trial Closing Statements
- Final statements of defendants devotion to the
communitythe service of my beloved
Fatherland.to overcome tremendous losses among
the ranks of our comradesgood of mankindserve
the good of humankindendeavor of mankind and was
morally as well as medically justifiedI never
failed in my duty to mankind
38The Nuremberg Trial Verdict
- 16 were found guilty
- 7 received the death penalty by hanging
- 5 life in prison
- 7 were acquitted
- Courts judgment included The Nuremberg Code
- Consists of 10 basic principles to govern medical
experimentation
39The Nuremberg Code
- 1. Voluntary consent is absolutely essential
- 2. Experiment should yield useful results,
unobtainable by other methods - 3. Based on animal experimentation
- 4. Avoidance of unnecessary physical or mental
suffering and injury - 5. Death or disabling injury should not be
expected outcomes
40The Nuremberg Code
- 6. Degree of risk should not exceed expected
importance - 7. Protection against injury, disability, death
- 8. Scientifically qualified persons
- 9. Subject may withdraw from experiment
- 10. Discontinuation if experiment is likely to
result in injury, disability, or death
41The Nuremberg Codes Legacy
- Refocused the medical ethos on the primacy of the
patient as an individual - Serves as blueprint for todays principles that
ensure the rights of subjects in medical research - World Medical Association Declaration of
Helsinki, 1964 Ethical Principles for Medical
Research Involving Human Subjects
42The United States
- Code applies to them and not us
- ..good code for barbarians but an unnecessary
code for ordinary physicians..
43Human Experimentation in the United States
- Tuskegee syphilis experiment
- Human radiation experiments
- Experiments where known effective treatments
withheld - Injection/implantation of infective agents and
cancer cells
44The Modern Medical Ethos
- Scale of Worth
- Primacy of the individual patient and justice and
equity in medical care - Science needs to have concern for its human
implications - Medical Hubris
- Power of excessive certainty, especially with
respect to public policy - Equity and fairness in delivery of health care
45The Modern Medical Ethos
- Core values of medicine require protection,
especially from informed, engaged, and concerned
professionals dedicated to the practice of
medicine
46Should the Data be Used?
- Is the data accurate? Scientifically flawed?
Skewed by political imperatives? - Does its use imply complicity or acceptance?
- Does its use demean medicine?
- An intangible memorial to the victims?
47Modern Implications
- Human Genome Project
- Involvement of physicians in execution of
convicted criminals - Racial inequalities in access to healthcare
- End-of-life issues
- Stem Cell research
- Abortion
- Cloning
- Treatment of prisoners, including forced feeding
48References
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New England Journal of Medicine. 1949 241 39-47 - Annas, G. and M. Grodin, Eds. The Nazi Doctors
and the Nuremberg Code Human Rights in Human
Experimentation. New York Oxford University
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from the Third Reich. JAMA. 1996 276(20)
1657-1661 - Barondess, J. Care of the Medical Ethos
Reflections on Social Darwinism, Racial Hygiene,
and the Holocaust. Annals Internal Medicine.
1998 129 891-898 - Baumslag, N. Murderous Medicine Nazi Doctors,
Human Experimentation, and Typhus. Westport, CT
Praeger, 2005
49References
- Beecher, H.K. Ethics and Clinical Research. New
England Journal of Medicine. 1966 274 1354-1360 - Bogod, D. The Nazi Hypothermia Experiments
Forbidden Data? Anaesthesia. 2004 59 1155-1156 - Geiderman, J.M. Ethics Seminars Physician
Complicity in the Holocaust Historical Review
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Useful Bodies Humans in the Service of Medical
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Johns Hopkins University Press, 2003 - Grodin, M. and G. Annas. Legacies of Nuremberg
Medical Ethics and Human Rights. JAMA. 1996
276(20) 1682-1683
50References
- Kater, M. Doctors Under Hitler. Chapel Hill
University of North Carolina Press, 1989 - Katz, J. The Nuremberg Code and the Nuremberg
Trial A Reappraisal. JAMA. 1996 276(20)
1662-1666 - Lefor, A. Scientific Misconduct and Unethical
Human Experimentation Historic Parallels and
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51References
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Some Myths and Misconceptions. Perspectives in
Biology and Medicine. 2000 43 335-346 - Seidelman, W. The Legacy of Academic Medicine
and Human Exploitation in the Third Reich.
Perspectives in Biology and Medicine. 2000 43
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