Breve Histria da Gentica

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Breve História da Genética

• Fontes Genetics in context ( www.esp.org)
  Nobel Organization (www.nobel.se)
• A History of genetics (A.H.Wturtevant)

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Timeline
1600
1700
1800
1900
2000
Genética das populações
Genética Molecular
Período Pré - Mendel
1866-1900
1676 - Nehemiah Grew 1677 - Leeuwenhoek 1691 -
Camerarius
1809 Lamarck 1819 Herbert 1820 - Nasse 1827
Lecoq 1823 - Amici 1839 Gärtner 1853 -
Thuret 1855 Naudin 1855 - Mendel 1856
Pringsheim 1861 - deBari 1865 - Wichura 1868
Darwin
1744 Maupertuis 1760 Lineu 1761
Kölreuter 1779 M. Lout
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Idade Antiga
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Periodo Pré-Mendel (I)
Spermatozoïd with a fetus (N.Hartsoeker 1694)
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Periodo Pré-Mendel (II)
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Periodo Pré-Mendel (III)
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Mendel

• Summary of Mendel's Results
• The F1 offspring showed only one of the two
  parental traits, and always the same trait.
• Results were always the same regardless of which
  parent donated the pollen (was male).
• The trait not shown in the F1 reappeared in the
  F2 in about 25 of the offspring.
• Traits remained unchanged when passed to
  offspring they did not blend in any offspring
  but behaved as separate units.
• Reciprocal crosses showed each parent made an
  equal contribution to the offspring.
• Mendel's Conclusions
• Evidence indicated factors could be hidden or
  unexpressed, these are the recessive traits.
• The term phenotype refers to the outward
  appearance of a trait, while the term genotype is
  used for the genetic makeup of an organism.
• Male and female contributed equally to the
  offsprings' genetic makeup therefore the number
  of traits was probably two (the simplest
  solution).
• Upper case letters are traditionally used to
  denote dominant traits, lower case letters for
  recessives.

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1866-1900 (I)
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1866-1900 (I)
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1866-1900 (I)
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A Redescoberta
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A Genética de Populações (I)
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A Genética de Populações (II)
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A Genética Molecular (I)
Macklyn McCarty
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A Genética Molecular (II)
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A Genética Molecular (III)
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A Genética Molecular (IV)
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A Genética Molecular (V)
watson
Crick
wilkins
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A Genética Molecular (VI)
Holley
Khorana
Nirenberg
Delbrück
Hershey
Luria
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A Genética Molecular (VII)
P.Berg
w.Gilbert
F.Sanger
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A Genética Molecular (VIII)
M.Smith
K.Mullis
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A Genética Molecular (IX)
E.Wieschaus
E.Lewis
M.Smith
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A Genética Molecular (X)
S.Brenner
Horvitz
Sulston