Title: The National Marrow Donor Program: A resource for unrelated donor transplantation
1The National Marrow Donor Program A resource for
unrelated donor transplantation
- Dennis L. Confer, M.D.Chief Medical Officer,
NMDP - June 2, 2004
2Who is the NMDP?
- 501(c)(3) Non-profit corporation
- Headquartered in Minneapolis, Minn
- The worlds largest network facilitating
unrelated donor transplants - Since 1987, NMDP has held the federal contract to
operate the National Bone Marrow Donor Registry
3NMDP Mission Statement
- Extend and improve life through innovative
cellular transplant therapies
4Transplant Activity since 1987through May 31,
2004
- 18,927 Total Transplants Facilitated
- 14,917 Bone Marrow Transplants
- 3,679 PBSC Transplants
- 331 Cord Blood Transplants
5National Marrow Donor Program Adult Donors
CBUs April 30, 2004
Adult Donors
CBUs
6 The NMDP Network
155 Transplant Centers(38 International)
89 Donor Centers(7 International)
9 Recruitment Groups
86 Apheresis Centers
Search Tracking and RegistrySTAR
104 Collection Centers(17 International)
13 Cord Blood Banks
Research Sample Repository
3 HLA TypingRepositories
22 HLA TypingLaboratories
7 The NMDP Link Products
Transplant Centers TRANS Link
Donor Centers STAR Link
Search Tracking and RegistrySTAR
HLA TypingRepositories CRIS Link
Cord Blood Banks CORD Link
FORMS NetTM
8NMDP Infrastructure
- Office of Patient Advocacy
- Membership and Quality Systems
- Data submission requirements
- Adverse event reporting
- Public and professional education
- Search and transplant services
9Why Cord Blood?
10Matching Adult Donors for Patients over the
History of the NMDP
Percent of Patients with at least one HLA-A, -B
-DRB1 Potential Match
11Matching Adult Donors for Patients over the
History of the NMDP
Percent of Patients with at least one HLA-A, -B
-DRB1 Potential Match
12Matching Adult Donors for Patients By Number of
Donors
Percent of Patients with at least one HLA-A, -B
-DRB1 Potential Match
Number of HLA-A, -B and -DR Typed Donors
13Umbilical Cord Blood
- Major Advantage
- Less stringent HLA matching requirement
- Additional Advantages
- Ready availability
- Minimal donor risk
14NMDP Cord Blood Bank Network
- LifeCord, Gainesville
- Bonfils Cord Blood Services, Denver
- Ashley Ross Cord Blood Program, San Diego
- St. Louis Cord Blood Bank, St. Louis
- ITxM Cord Blood Services, Glenview
- Childrens Hospital of Orange County,
Orange - New Jersey Cord Blood Bank, Camden
- Puget Sound Blood Center/Northwest Tissue Center,
Seattle - ARC Western Area Community CBB, Portland
- StemCyte, Inc., Arcadia
- ARC North Central Blood Services, Cord Blood
Program, St. Paul - J.P. McCarthy Cord Stem Cell Bank, Detroit
- Carolinas Cord Blood Bank, Durham
13 Cord Blood Banks 30,874 Cord Blood Units are
currently listed 1,000 Transplants331 through
the NMDP
15NMDP Cord Blood Committee
- Membership includes
- Transplant physicians
- Cord blood bank directors
- Scientists
- Ethicists
- Obstetricians
- NMDP staff
- HRSA representatives
- Informal participation by FDA
16NMDP Cord Blood Committee
- Subcommittees address
- Quality standards
- Proficiency and quality systems
- Information technology
- Collections and outreach
- Bank/TC interface
- Economics and contracts
- Education and professional education
- Research and ethics
17TRANS Link displays all matches
18Summary
- NMDP is dedicated to serving the needs of
patients - Cord blood offers the potential to match many
more patients and is expected to play a major
role in the future of unrelated donor transplant
therapies - With federal support, the NMDP has developed,
operates and continues to expand the worlds
largest network for unrelated donor transplant
therapies
19Summary, continued
- NMDP supports federal funding to expand our
nations cord blood inventory - Investment of public dollars requires
accountability, efficiency and effectiveness to
maximize the benefit to patients - NMDP supports the IOM Committees efforts and is
ready to provide information and assistance as
needed