Resveratrol or caffeine induce. p53 Ser 15 phosphorylation

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Hormel Institute, University of Minnesota
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MEMORANDUM OF AGREEMENT ESTABLISHING THE HORMEL
INSTITUTE AUSTIN, MINNESOTA AS A UNIT OF THE
GRADUATE SCHOOL UNIVERSITY OF MINNESOTA CERTIFICA
TE OF INCORPORATION AND BY LAWS OF THE HORMEL
FOUNDATION AUSTIN MINNESOTA NOVEMBER 30, 1942
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Legacy of George A. Hormel and Jay C. Hormel

• Jay C. Hormel resolved that the major portion of
  the Hormel Foundation income should benefit
  scientific research
• Good research means training, talent,
  facilities, and hard work.

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• Early Projects and Emphasis
• preservation of foods
• Development of a miniature pig for use in
  studying human disease
• the nations leading center of scientific
  research in the field of lipids
• Discovery of (and coining of the terms) omega 3
  and omega 6 fatty acids and their relevance to
  health

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Dr. Zigang Dong Dr. Ralph T.Holman
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Unique Features of The Hormel Institute

• Employs some of the world's leading scientists
  working on cutting edge research.
• Many collaborative research partners
• University of Minnesota Cancer Center
• Mayo Clinic
• Rutgers University
• the University of Arizona
• Access to hundreds of natural compounds for
  testing in the prevention and treatment of
  cancer.

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Hormel Institute Scientists 1) Use the tools
of molecular and cellular biology a) to
evaluate changes in cancer cells b) to
determine the role of mutant cancer genes
in producing changes in cell function.
2) Attempt to understand the changes seen in
cancer cells compared with normal cells. 3) A
major focus of the researchers is the development
of novel natural compounds that are non-toxic
to normal tissues and cells but highly effective
in preventing and/or treating various types of
cancers.
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To win the war against cancer

• We must know the enemy--understand
  carcinogenesis.
• Prevent or treat cancer by targeting specific
  cancer genes and/or proteins.

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Arsenic,UV,TPA
EGFR
PKC
Rac, Rho
Ras
TAK
Raf
MKK 1-5
MKK 3/6
MKK 4/7
MEK1/2
P
P
AP-1
P
P
TCF Elk1
Jun
P
P
TCF Elk1
ATF2
Jun
Fos
Jun
Fos
P
c-fos
c-jun
P
AP-1
Jun
Jun
Apoptosis Tumor
target genes
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Biophysics
Cancer Biology
Cellular Developmental Biology
Cellular Molecular Biology
Nutrition Metabolism
Membrane Biochemistry
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Strategic Assets of the Hormel Institute,
University of Minnesota

• A statement of our strategic assets in light
  of the criteria outlined in Advancing the Public
  Good Securing the Universitys Leadership
  Position in the 21st Century

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1. Centrality to Mission

• The Hormel Institute has achieved excellence in
  basic research
• In the past year we were published 23 times
  including twice in Nature.
• In the past year 43 of our submitted grant
  applications were funded.
• Each faculty member has at least one R01 grant
  and in several cases more than one.

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POST-TRANSLATIONALMODIFICATION OF P53 IN
TUMORIGENESIS
Ann M. Bode and Zigang Dong
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POST-TRANSLATIONALMODIFICATION OF P53 IN
TUMORIGENESIS
Ann M. Bode and Zigang Dong
Resveratrol EGCG Caffeine Theaflavins
Resveratrol or caffeine induce p53 Ser 15
phosphorylation
Resveratrol EGCG Caffeine Theaflavins
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2. Quality, Productivity, Impact

• The Hormel Institute has experienced rapid recent
  growth in the past three years.
• Since 2002 the Hormel Institute has grown from 50
  staff to over 90 staff.
• National Institutes of Health (NIH) funding has
  tripled.
• This rapid growth continues as additional faculty
  are being recruited.

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3. Uniqueness Comparative Advantage

• The Hormel Institute has focused research on the
  most deadly disease cancer.
• The potential of Hormel Institute research is
  non-toxic, natural alternatives to chemotherapy
  and novel approaches to cancer prevention.
• Our published and widely known research on green
  tea and ginger are only two examples of many more
  compounds that will help people prevent and treat
  cancer without the toxicity of chemotherapy.

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4. Enhancement of Academic Synergies

• The Hormel Institute has a growing portfolio of
  impressive collaborators
• Mayo Clinic
• University of Minnesota Cancer Center
• University of Arizona
• Rutgers University
• Our jointly sponsored symposia with the Mayo
  Clinic Cancer Center Dietary Factors and Cancer
  Prevention and Targeting Carcinogenesis continue
  to inform the field of chemoprevention

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• Agricultural Biotechnology on Natural
  Compounds as Anti-Cancer Agents together we are
  initiating and coordinating systematic testing of
  hundreds of dietary factors isolated from natural
  agricultural sources.

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5. Demand and Resources

• Each additional staff position created at the
  Hormel Institute brings a high paying job to
  rural Minnesota.
• The commercialization of Hormel Institute
  discoveries will create additional economic
  development and improve the quality of life for
  Minnesotans and the quality of health for people
  throughout the world.
• Local economic development entities (Southern
  Minnesota Initiative Foundation, City of Austin
  and Development Corporation of Austin) understand
  our value and enthusiastically support the Hormel
  Institute.

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Matt Kramer, Commissioner of Department of
Employment and Economic Development

• I was amazed when I went down there what a
  jewel that facility is, he said, All along, the
  states bioscience initiative has focused on
  promoting Minnesotas strengths. One of our
  strongest industries has been food manufacturing.
  What the Hormel Institute can do is show through
  their research that food compounds can play a
  critical role in disease management.
• Gene Goddard, bioscience industry
  specialist with the Minnesota Department of
  Employment and Economic Development

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• What impresses me today is the open-mindedness
  of the researchers here.
• Congressman Gil Gutknecht

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• Senator Norm Coleman views cancer research at the
  Hormel Institute as valuable and important work
  and sees the jobs created here as an example of
  his Rural Renaissance.

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6. Efficiency Effectiveness

• There is a large return in the form of
  publications, grants, and intellectual property
  resulting from investments made in the Hormel
  Institute, University of Minnesota.

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7. Development Leveraging of Resources

• The Hormel Institute is the legacy of Jay C.
  Hormel, who intended that Hormel Institute
  conduct research in the biomedical sciences.
• The Hormel Foundation has faithfully supported
  the Hormel Institute since 1942.
• The Hormel Foundation is the majority shareholder
  of the Hormel Foods Company.
• The Hormel Foundation will become one of the
  worlds largest foundations supporting medical
  research in the coming decades.

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Hormel Institute, University of Minnesota
Outreach to Southern Minnesota

• Summer Undergraduate Research Experience Program
  (S.U.R.E.)
• Southern Minnesota Internet Group internet
  service provider to over 5,000 greater Minnesota
  customers. SMIG is endeavoring to provide
  wireless internet coverage for all of Austin.
  Wireless Austin would make Austin one of the few
  cities in the nation with city wide wireless
  access.

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Keys to the Future

• The Hormel Institutes aim is to build bridges
  that effectively span the gap between basic
  laboratory research and clinical application.
• Next Steps
• Meeting the needs created by our rapid expansion
• Achieving critical mass for our faculty and
  sections

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Jay Hormel would be very proud of the Institute
if he were alive today

• Mr. Richard Knowlton
• Chairman, Hormel Foundation
• On the occasion of the
• Hormel Institutes
• 60th Anniversary Celebration

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Questions and Answers

• Zigang Dong, M.D., Dr.P.H.
• Executive Director
• and Hormel-Knowlton Professor
• Hormel Institute, University of Minnesota
• 801 16th Ave NE
• Austin, MN 55912
• 507-437-9600
• zgdong_at_hi.umn.edu
• www.hi.umn.edu