Synthetic Liver Lesion Models

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Synthetic Liver Lesion Models

• Group Members Peng Ying, Ronghua Yang, Bin Luo
• Mentors Dr. Michael Awad, Dr. Michael Choti,
• Dr. Russel H. Taylor
• Affiliates Joshua Leven, Emad Boctor

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Background

• 1 million cases of primary liver cancer per year
  detected worldwide
• Epidemic of Hepatitis C is expected to increase
  liver tumor prevalence
• 5 year survival rate is less than 10

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Typical Stage I Tumor- localized- no greater
than 2 cm
Ultrasound Image

• Stage I IV

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Current Procedure

• Radiofrequency Ablation
• Cryosurgery
• Surgical resection
• Liver transplant
• Intra-arterial Infusion Pump

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RF Ablation in Detail
After RF Ablation No continued uptake of
contrasting material
Before RF Ablation - Takes up contrast material,
white on CT scan
Images from Massachusetts General Hospital
website
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Current Research

• Joshua Leven microultrasound surgical probe
• Emad Boctor 3D elastography

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Project Description

• Create liver lesion
• Various size
• Various density/elasticity
• Visibility by Ultrasound/X-ray
• Ability to introduce needle within lesion
• Devise minimally invasive methods to implant
  synthetic lesions both in vivo and in vitro
• Construct a phantom liver model

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Models in Development

• Marble
• unable to introduce needle
• Agro gel
• cant mimic all visibility conditions
• Balloon Catheter (in vitro)
• premature solidification of agro gel
• Other concerns
• shape consistency, implantable

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Deliverables

• Minimal
• Reusable spherical molds of various sizes
• Expected
• Model different types of echogenicity
• Model a range of elasticity
• Maximum
• Protocol of creating realistic in vivo lesions
• Phantom liver model

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Dependencies

• BME machine shop for constructing the spherical
  molds
• Ultrasound devices at the Hopkins Medical School
  and Homewood campus
• In vivo testing with live animals use of
  hospital facility

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Budget
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Timeline
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Project Management
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References

• Moug SJ, Horgan PG, Leen E
• Contrast-enhanced ultrasonography during liver
  surgery (Br J Surg 2004 91 1165-1167).Br J
  Surg. 2005 Jan92(1)121-2
• Solbaiti L, Tonolini M, Cova L, Goldberg SN.
• The role of contrast-enhanced ultrasound in the
  detection of focal liver leasions.Eur Radiol.
  200111 Suppl 3E15-26.
• Yoshida H, Casalino D, Keserci B
• Wavelet-packet-based texture analysis for
  differentiation between benign and malignant
  liver tumors in ultrasound images
• 2003 Phys. Med. Biol. 48
• Dr. Michael Awads grant purposal