Describe the steps in neurotransmission.

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Neurotransmission of signals

• Describe the steps in neurotransmission.
• Describe the ionic basis for neurotransmitter
  release.
• List the major neurotransmitters and describe
  their mode of action.
• Describe the basic organization of the nervous
  system.

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Conduction of Action Potentials
Figure 8-14a Conduction of action potentials
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Mechanism of Vg Na channels
Figure 8-10 Model of the voltage-gated channel
Na
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Neurocrines
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Neurocrines
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Possible mechanisms of NT action
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Neurotransmitters and Receptors

• ACh receptor (cholinergic)
• nicotinic
• muscarinic
• NE and E receptor (adrenergic)
• ?1 and ?2 (alpha)
• ?1 and ?2 (beta)

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Acetylcholine

• nicotinic receptor
• is a Na / Kchannel
• muscarinic receptor
• is a G-protein coupled receptor that links to
  2nd messenger five known forms

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• http//www.blackwellscience.com/matthews/neurotran
  s.html

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Acetylcholine synthesis
Figure 8-21 Synthesis and recycling of
acetylcholine at the synapse
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Norepinephrine/Epinephrine

• adrenergic receptors, alpha and beta
• are G-protein coupled receptors, linked to 2nd
  messengers

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Neurotransmission of signals

• Describe the basic organization of the nervous
  system.
• List the steps in neurotransmission.

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Organization of the Nervous System
Text Figure 8-1
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http//biology.udayton.edu/Courses/BIO415/StudyGui
des/images/05/Fig11_Part_2_Movie.gif