Multifunctional bioresorbable biocompatible coatings with biofilm inhibition and optimal implant fix

1
Multifunctional bioresorbable biocompatible
coatings with biofilm inhibition and optimal
implant fixation
IP-SME MEDDELCOAT 2006-2010
Background
Most common reasons for revision surgery of
implants are loosening (65), dislocation (9)
and infection (7). The revision rate of
orthopaedic implants is between 10-20 after
15-20 years. For dental implants it is 15 over a
5-year period. Biofilm formation is the major
pathogenic factor.
Objectives
The project aims at gaining the scientific and
processing knowledge to develop the next
generation of multifunctional, bioactive,
biocompatible coatings for orthopaedic and dental
implants with biofilm inhibition and optimal
implant fixation. The envisaged radical
innovations and major breakthroughs are

• New substrates and coatings with enhanced
  biocompatibility
• Radically new or improvement of existing coating
  techniques for processing bioresorbable and
  biocompatible coatings with a graded interface
  and tailored porosity
• In-depth understanding of implant
  substrate/coating/bone interface structure,
  design and engineering of optimal implant
  fixation
• Knowledge on biofilm formation and inhibition
• Formulation and evaluation of biofilm inhibitors
  incorporated into the coating

Porous bioactive coating processing techniques

• Amongst the techniques to realise the porous
  bioactive coating are
• Vacuum plasma spraying
• Sol-gel processing
• Electrophoretic deposition
• Selective laser sintering
• Dip coating
• Plasma Enhanced Chemical Vapour Deposition
  (PE-CVD)
• Laser assisted microwave processing

Expectations
Reducing the need for implant revision due to
loosening and infection by designing and
engineering an implant surface to optimise
fixation, promoting osteointegration by applying
a bioactive coating and incorporating a biofilm
formation inhibiting function.
LEMI
www.meddelcoat.eu