CCCNHC Pincer Complexes: A General Method of Preparation Critical for Catalysis

1
CCC-NHC Pincer Complexes A General Method of
Preparation Critical for Catalysis
T. Keith Hollis, Department of Chemistry
Biochemistry, The University of Mississippi,
Oxford, MS
A dramatically improved synthesis has been
accomplished using toluene as solvent with
sublimed Zr and elevated temperatures producing
upon cooling in excellent yield by filtration
analytically pure, X-ray quality crystals. This
methodology is being extended to other metals and
pure isolated complex is available for
transmetallation.
1.8 g, 67
E.A. calcd C, 37.19 H, 4.40 N, 9.86
found C, 37.19 H, 4.17 N, 9.79
C-N bond formation is one of the leading areas of
research in Organic Chemistry. Our ability to
make quaternary C-N bonds is still fledgling.
This newly synthesized complex is a highly
efficient catalyst for making C-N bonds for the
synthesis of pyrrolidine and piperidine rings
found in many medicinally active compounds.
Internal substitution on the alkene precursor is
tolerated producing nitrogen substituted
quaternary carbon.