Alternative Approaches to Medicine: Living Well Beyond 100 Years of Age ______________________ Copin

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Alternative Approaches to Medicine Living Well
Beyond 100 Years of Age______________________Cop
ing With Change Conference
The Ohio State University Retirees' Association

• Glen Aukerman, MD
• Medical Director
• The Ohio State University
• Center for Integrative Medicine

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Objectives

• Participants will have greater understanding of
• Complementary and Alternative Medicine (CAM) Use
  Among Older Adults
• Important to Communicate with your doctors about
  herbs, nutrition, nutritional supplements
• Credible information about supplements and herbal
  products, their safety and effectiveness
• Nutritional needs for increased functioning and
  reduced effects of aging
• How other Systems of Health-Care, Ayurveda

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Complementary and Alternative Medicine (CAM) Use
Among Older Adults

• Older adults increasingly use complementary and
  alternative medicine
• 2000 Health and Retirement Study showed
• 88 of respondents 65 years and older used CAM
• Dietary supplements 65
• Chiropractic 46
• Age correlated with use of dietary supplements
  and personal practices
• inversely correlated with alternative
  practitioners
• Men reported less CAM use than women
• Men use more chiropractic and personal practices
• Blacks and Hispanics used fewer dietary
  supplements, less chiropractic
• more personal practices than Whites
• Advanced education correlated with fewer
  chiropractic visits
• more dietary and herbal supplement and personal
  practices use
• More alternative practitioner use
• Higher income, functional impairment, alcohol use
  and frequent physician visits correlated
• No association between CAM use and number of
  chronic diseases
• Ness J, Cirillo DJ, et al. Use of Complementary
  Medicine in Older Americans results from the
  Health and Retirement Study. The Gerontologist.
  45516-524 (2005)

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CAM Use Among Rural Older Adults

• CAM use, older rural white and black adults
• 41-75 of older adults were using some form of
  CAM
• Most common CAM used by this population were
• prayer 85
• vitamins 83
• exercise 64
• Other forms of CAM reported were meditation,
  herbs, chiropractic, glucosamine, and music
  therapy
• Money was spent on CAM
• 45 of respondents reported spending on CAM
• Note may be due to limited income, lack of
  insurance coverage for CAM, and limited
  availability of CAM in rural areas
• Cuellar N, Aycock T, Cahill B, Ford J.
  Complementary and Alternative Medicine Use by
  African American and Caucasian American Older
  Adults in a Rural Setting. BMC Complementary and
  Alternative Medicine 2003, 38

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CAM Use Among Urban Older Adults

• Cross-sectional analysis of medical charts 65
  years of age, urban academic hospital
  geriatrics practice
• Elements measured included
• a) CAM use Prevalence 64
• b) proportion of CAM supplements and herbs
  (CAMsh) reported by patients and documented in
  patients charts 35
• c) 46 of patients reporting taking CAMsh with
  anticoagulant activity (ginger, gingko, garlic,
  vitamin E) while concomitantly taking prescribed
  anticoagulant medications
• 52 took a prescribed anticoagulant (per chart)
• 48 took CAM but not prescribed anticoagulants
• d) 46 of patients for whom the CAM
  anticoagulant was not documented in the chart
• Cohen RJ, Ek K, Pan CX. Complementary and
  Alternative Medicine Use by Older Adults. The
  Journals of Gerontology Series A Biological
  Sciences and Medical Sciences 57M223-M227 (2002)
  Ther Gerontological Society of America

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CAM Use Among Older Adults

• Conclusions
• CAM use is prevalent among older adults
• Health care professionals should recognize that
  CAM may be used very differently among a variety
  of racial and ethnic backgrounds
• Patients often do not report or under-report CAM
  use
• CAM frequently not documented in the patients
  chart if reported
• Health care professionals should encourage
  patients to discuss CAM activity, particularly
  vitamin/herb supplements, as these may cause
  potentially harmful drug-supplement interactions

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Increased Life Expectancy Last Century

• 30 years added to ave. US life expectancy
• 100 years ave American life span expected this
  century
• Decreases in early-life mortality
• Decreases in mid-life mortality from medical
  advances
• Curative medicine will play a lesser role
• Nutrition and Supplements will play larger role
• Aging population has increased health care costs
• Costs will increase more as we have even longer
  lives
• Unless we become more healthy through
  Nutrigenetics
• Establishing and safeguarding optimal health from
  early life must become increasingly important
• Concerns for governments and health care
  providers
• Allocate resources wisely
• Ensure and maintain a high quality of life in the
  population through better nutrition and
  fitness

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The Future of Living Well to 100

• Healthy aging presents an enormous challenge
• Advances in biological sciences provide the
  knowledge and tools needed to
• understand nutrition at genetic and molecular
  levels and
• elevate the scientific basis underlying
  nutritional recommendations
• Understanding roles requires interdisciplinary
  cooperation of
• nutrition
• genetics,
• inflammation
• Developing partnerships among specialties to
  promote the goal of healthy aging
• come together as a science community
• generate the evidence base to influence
  recommendations
• Value of nutrition and genetics in achieving
  healthy aging
• Am. J. Clinical Nutrition, Feb 2006 83 488s -
  490s. Gordon W Duff, Peter Libby, José M
  Ordovas, and Philip R Reilly

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The Different Paths to 100

• Most centenarians do not have significant
  disability
• 90 of centenarians functionally independent _at_
  ave. age of 92 years
• A more enabling point of view emerges to achieve
  extreme old age
• The older an individual gets, the healthier he or
  she has been
• Centenarians show
• Relative resistance to age-related diseases
• Slower aging
• Where are we heading
• 1 centenarian per 10,000 persons in the United
  States NOW
• 1 centenarian per 5,000 persons for
  industrialized nations SOON
• Ability to survive to extreme old age appears to
  be the result of
• Complex combination of
• Genetics,
• Environment
• Lifestyle (Diet, Exercise,Social Activities), and
  Luck
• The Future Path lies in
• Better Perinatal Nutrition Omega-3, Nutrients
• Genetics of the Very Old
• Identifying the molecular drivers of longevity or
  mortality omega 3/6 ratio

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Starting Down the Right Path Nutrition
Connections With Chronic Diseases of Later Life

• Prevention-oriented life cycle approach is
  critical to
• Establishing and maintaining health throughout
  life
• Delay and compress morbidity (sickness) and
• Decrease the social toll associated with chronic
  disease and disability for as long as possible
  into old age
• Good evidence that early nutrition affects key
  risk factors for
• Chronic degenerative diseases of middle and later
  life, such as
• Osteoporosis and
• Cardiovascular disease
• Influence of nutrition on health status and
  morbidity supports primary, secondary, and
  tertiary prevention of disease and intervention
  strategies at each point in the process
• Enable people to live well, longer
• Minimize chronic disability
• Johanna Dwyer, Am. J. Clinical Nutrition, Feb
  2006 83 415S - 420S

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Genetics of Aging Implications for Drug
Discovery

• Aging is not a passive activity,
• But an actively regulated metabolic process
• Specific genes identified that regulate aging,
• Aging and Longevity are only partially under
  genetic influence
• Rest of Gain is from Nutrition
• It is possible to increase life span by
  environmental modification
• caloric restriction can increase life span
• dysregulation of glucose homeostasis is a
  hallmark of aging in humans
• type 2 diabetes, a disease of glucose
  homeostasis, is a form of accelerated aging
• Aging and Diabetes are both common risk factors
  for a wide range of diseases
• Aging and Diabetes are related at a molecular
  level
• Andrew S Greenberg and Martin S ObinAm. J.
  Clinical Nutrition, Feb 2006 83 461s - 465s
• Bard J Geesaman, Am. J. Clinical Nutrition, Feb
  2006 83 466S - 469S

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Influence of Human Genetic Variation on
Nutritional Requirements

• Genetic variation is known to affect food
  tolerances among human subpopulations and may
  also influence dietary requirements, giving rise
  to the new field of nutritional genomics and
  raising the possibility of individualizing
  nutritional intake for optimal health and disease
  prevention on the basis of an individual's genome
• Gene-diet interactions are complex and poorly
  understood, the use of genomic knowledge to
  adjust population-based dietary recommendations
  is not without risk
• Current recommendations target most of the
  population to prevent nutritional deficiencies,
  inclusion of genomic criteria may indicate
  subpopulations that may incur differential
  benefit or risk from generalized recommendations
  and fortification policies
• Current efforts to identify gene alleles that
  affect nutrient utilization have been enhanced by
  the identification of genetic variations that
  have expanded as a consequence of selection under
  extreme conditions
• Patrick J Stover, Am. J. Clinical Nutrition,
  Feb 2006 83 436S - 442S

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Evidence for Genetic Variation A Factor in
Maintaining Health

• Influence of Genetics subtle, complex, not
  conforming to simple Mendelian patterns of
  inheritance as is seen with single-gene disorders
• Genetic Variation can influence the propensity
  for the initiating event, the progression to a
  clinical disease state, and the trajectory of
  disease
• Interleukin 1 example genetic variations
  affecting complex diseases is provided by the
  interleukin 1 family of cytokines
• Key role in mediating inflammation central
  component of many chronic diseases
• Coronary artery disease
• Rheumatoid arthritis
• Research has identified many sequence variations
  in regulatory DNA of the genes coding for
  important members of the interleukin 1 family,
  and these variations are associated with
  differential effects on the inflammatory response
• These in turn alter the risk of some diseases in
  which inflammation plays a role and also affect
  physiologic responses, such as the inflammatory
  response to exercise. As this new genetic
  knowledge is developed and extended, it may be
  possible to make health care interventions at an
  earlier stage, before clinical disease is
  established, rather than after tissues have been
  permanently damaged
• Gordon W Duff, Am. J. Clinical Nutrition, Feb
  2006 83 431S - 435S

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Chronic Illnesses Diet-Related Health Problems
Are the Most Serious Threat to Public Health

• Sixty-five percent of US adults aged 20 years
  overweight or obese
• 280,184 deaths per year attributable to obesity
• 64,000,000 Americans have cardiovascular
  disease (CVD) 38.5 deaths
• Leading cause of mortality in the United States.
• 50,000,000 Americans are hypertensive
• 11,000,000 Americans have type 2 diabetes, and
• 37,000,000 adults have high-risk total
  cholesterol (240 mg/dL)
• Postmenopausal women aged 50 years
• 7.2 have osteoporosis and
• 39.6 have Osteopenia
• Osteoporotic hip fractures 20 excess mortality
  in the year after fracture
• Cancer 25 of all deaths in the United States,
• is the second leading cause of death
• one-third of all cancer deaths are due to
  nutritional factors, including obesity

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Nutrients Restore The Immune System

• Changes in USDA Food Composition Data for 43
  Garden Crops, 1950 to 1999, Protein, Ca, P, Fe,
  Pyridoxine, and Vit C all decreased
• The Fundamentally Altered 7 Crucial Nutritional
  Characteristics of Modern Diets and the Impact of
  Health in The 21st Century
• Associations of Mortality With Ocular Disorders
  and an Intervention of High-Dose Antioxidants and
  Zinc, Age-Related Eye Disease Study
• Relation Between Dietary N3 and N6 Fatty Acids
  and Clinically Diagnosed Dry Eye Syndrome in
  Women when om 6 om 3 61
• The Western Diet Frequently Contains Excessive
  Saturated and Trans Fatty Acids, Too Little N3
  PUFAs versus excess N6 PUFAs
• Western Diet Yields a Net Acid Load Renal
  Failure
• Latex Exposure comes from inhaled auto tires but
  Immune system is depressed when we eat foods
  laden with naturally occurring latex
• Role of Thiamine and B Complex in High Calorie
  Malnutrition

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Inflammation and Neurodegenerative Diseases

• Mental Fitness Decline in Alzheimer Disease
  accompanies
• Physical changes in the brain, including the
  development of
• characteristic plaques and
• Neurofibrillary tangles
• Pathogenesis of those changes is not clear
• Activation of microglia in response to injury,
  illness, aging, or other causes begins a cascade
  of events characterized as an inflammatory
  process
• Cascade is mediated at first by the
  proinflammatory cytokine interleukin 1, which is
  over expressed by the activated microglia
• Interleukin 1 causes neuronal death, which
  activates more microglia, which in turn release
  more interleukin 1 in a self-sustaining and
  self-amplifying fashion
• Over a period of years, this slow smoldering
  inflammation
• in the brain destroys sufficient neurons
• to cause clinical signs of Alzheimer disease
• W Sue T Griffin,Am. J. Clinical Nutrition, Feb
  2006 83 470S - 474S

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The Fundamentally Altered 7 Crucial Nutritional
Characteristics of Modern Diets
Food staples and food-processing procedures
introduced during the Neolithic and Industrial
Periods have fundamentally altered 7 crucial
nutritional characteristics of ancestral hominin
diets 1) glycemic load 2) fatty acid composition
omega 63 ratio 3) macronutrient composition 4)
micronutrient density 5) acid-base balance 6)
sodium-potassium ratio, and 7)
fiber content
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Changes in USDA Food Composition Data From1950
to 1999 for 43 Garden Crops

• All 43 fruits and vegetables tested show
  statistically reliable declines (R nutrients
• Protein, 6
• Calcium,
• Phosphorus,
• Iron,
• Riboflavin 38
• Vitamin C
• Conclusions
• Declines are generally changes in cultivated
  varieties between 1950 and 1999, in which there
  may be trade-offs between yield and nutrient
  content
• Observations
• Need to replace those nutrients not available in
  current Western Food Supply
• Donald R. Davis, PhD, FACN, Melvin D. s, PhD and
  Hugh D. Riordan, MD

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Nutritional Needs As We Age

• Nutritional Needs for Increased Functioning and
  Reduced Effects of Aging in the Elderly
• Avoid Latex in Foods,
• Decrease Gluten and Omega-6 as much as possible
• Replace Nutrients no longer in our Food Supply

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Western Diet Yields a Net Acid Load

• Western net acid load estimated to be 50 mEq/d
• Adults on the standard US diet sustain a chronic
  low-grade pathogenic metabolic acidosis that
  worsens with age as kidney function declines
• Virtually all preagricultural diets were net base
  yielding because of the absence of cereals and
  energy-dense, nutrient-poor foods
• introduced during the Neolithic and Industrial
  Eras
• displaced base-yielding fruit and vegetables
• base-producing diet, the norm throughout most of
  hominin evolution
• Health benefits of a net base-yielding diet
  include preventing and treating
• Osteoporosis
• Age-related muscle wasting
• Calcium kidney stones
• Hypertension
• Exercise-induced asthma
• Slow progression of age / disease-related
  chronic renal insufficiency

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Thiamine Deficiency

• Modern Western diet is loaded with simple
  carbohydrates
• B-Vitamin deficiency is extremely widespread
• Thiamine is very high in this deficiency because
  of its biochemical association with glucose
  metabolism
• Because of vitamin fortification of many foods
  and the relative affluence of our present culture
  we have no considered that obscure symptoms,
  particularly those that are generally termed
  functional, are of dietary origin
• Deficiency is direct result of years of high
  calorie diet and treatment with large doses of
  the appropriate vitamin/mineral supplementation
  is mandatory
• Physiological doses have no effect since the
  enzyme/cofactor bonding appears to be damaged or
  partially atrophied. (Need High Dose, not Mega
  Dose)
• Physicians become disenchanted when they treat a
  patient with low-dose supplementation and see no
  benefit
• The RDA of thiamine is 11.5 mg per day, but only
  in a biochemically healthy individual, and many
  physicians are under the impression that this
  kind of vitamin deficiency, if it occurs at all,
  is easily and quickly treated
• In the treatment of beriberi, it took very large
  doses of thiamine for months and there was often
  only partial recovery and sometimes none at all

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Clinical Features Now Emerge

• Clinical features of beriberi have been forgotten
  in modern medicine since it has been assumed
  that the classic deficiency diseases do not occur
  in developed societies
• Dysfunction in the autonomic system was a
  prominent part of the clinical expression of
  beriberi (21) and reversible autonomic
  dysfunction, associated with evidence of high
  calorie malnutrition, has been reported in recent
  times in the United States (22,23)
• Sweating, tachycardia, dermographia, wide
  unstable pulse pressure, attention deficit and
  other symptoms of autonomic dysfunction in
  children have been reported as functional
  dysautonomia (24)
• Relation between thiamine requirements and the
  intake of carbohydrates
• The influence of stepwise increases of
  carbohydrate intake on the status of thiamine in
  healthy volunteers under isocaloric conditions
  (25) An increase of dietary carbohydrate intake
  caused a decrease of plasma and urine levels of
  thiamine without affecting enzyme activities
• Thiamine Deficiency has been reported in
  refractory heart failure (36) and has occurred in
  epidemic form in Cuba involving 50,862 (461.4 per
  100 000) people
• Lesions included peripheral neuropathy,
  retrobulbar optic neuropathy, sensory and
  dysautonomic peripheral neuropathy, sensorineural
  deafness, dysphonia, dysphagia and spastic
  paraparesis (37,38). TD ataxia (39),
  post-gastrectomy polyneuropathy (40) and
  reversible autonomic neuropathy involving bladder
  dysfunction (41) have been described
• Natural Sources and Modern Antagonists to
  Thiamine
• Thiamine is present in lean pork and other meats,
  wheat germ, liver and other organ meats, poultry,
  eggs, fish, beans and peas, nuts, and whole
  grains
• Dairy products, fruit and vegetables are not good
  sources
• The RDA is 0.5 mg per 1000 kcal, adequate for a
  healthy individual consuming a healthy diet
• Considerable losses occur during cooking or other
  heat-processing of food
• Polyphenolic compounds in coffee and tea can
  inactivate thiamine so that heavy use of these
  beverages could compromise thiamine nutrition

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B-complex Vitamins Biochemical
Roles,Physiologic Roles of Co-enzyme Forms, and
Brief Description of Clinical Deficiency Symptoms
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Various Eye Disorders Predict Survival

• Various ocular disorders (eg, visual impairment
  and cataract and those in persons with diabetes
  mellitus, severe retinopathy, or visual
  impairment)reported to be significant predictors
  of a decreased life span, after extensive
  adjustment for potential confounders
• Cataract surgery has been associated with
  decreased survival in many studies
• Nuclear opacities associated with decreased
  survival
• Age-related macular degeneration (AMD) has not
  been found to be related to decreased survival in
  the few studies that have examined the
  relationship
• Ability to find an association is limited because
  few participants in these studies had advanced
  disease (neovascular AMD or geographic atrophy)
• Age or underlying disease related to the ocular
  conditions and mortality could explain the
  findings why ocular factors could be associated
  with decreased survival
• Loss of vision could have a direct effect on
  mortality if it results in a susceptibility to
  accidents such as fatal falls or in depression
  reported to increase mortality
• Cataracts may be markers of systemic processes
  that are associated with accelerated physiologic
  aging and earlier death
• Generalized oxidative damage play a role in
  cataract development, aging process
• Nutrients found helpful
• Centrum Silver
• Reverses Cataracts
• Omega-3 Fish Oil
• Reverses Dry Eyes Syndrome
• Zinc oxide 80 mg
• had lower mortality

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Associations of Mortality With Ocular Disorders
and an Intervention of High-dose Antioxidants
and Zinc

• Objective  To assess the association of ocular
  disorders and high doses of antioxidantsor zinc
  with mortality in the Age-Related Eye Disease
  Study (AREDS)
• Methods  AREDS is an ongoing, multicenter study
  of the clinical course of cataract and AMD. The
  study included a randomized clinical trial that
  evaluated the effect of high daily doses of
  selected oral supplements (vitamin C, 500 mg
  vitamin E, 400 IU beta carotene, 15 mg and
  zinc, 80 mg as zinc oxide with 2 mg of cupric
  oxide) on the incidence and progression of the 2
  conditions. A total of 4757 persons aged 55 to 81
  years at enrollment were entered into the study
  at 11 clinical centers between November 13, 1992,
  and January 15, 1998
• Results  During median follow-up of 6.5
  years, 534 (11) of 4753 AREDS participants died
• Advanced age-related macular degeneration (AMD)
  compared with participants with few, drusen had
  increased mortality (relative risk RR, 1.41
  95 confidence interval CI, 1.08-1.86)
• Advanced AMD was associated with cardiovascular
  deaths
• Visual acuity worse than 20/40 in one eye had
  increased mortality (RR, 1.36 95 CI,
  1.12-1.65)
• Nuclear opacity (RR, 1.40 95 CI, 1.12-1.75) and
  cataract surgery (RR, 1.55 95 CI, 1.18-2.05)
  were associated with increased all-cause
  mortality and with cancer deaths
• Zinc participants had lower mortality than those
  not taking zinc (RR, 0.73 95 CI, 0.61-0.89)
• Conclusions 
• The decreased survival of AREDS participants with
  AMD and cataract suggests that these conditions
  may reflect systemic rather than only local
  processes
• Improved survival in individuals randomly
  assigned to receive zinc requires further study

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Relation Between Dietary Omega3 and Omega6
Fatty Acids and Clinically Diagnosed Dry Eye
Syndrome in Women

• 32,470 women aged 4584 y were assessed Fatty
  Acid intakes using a validated food-frequency
  questionnaire and assessed Dry Eye Syndrome by
  using self-reports of diagnosed cases
• Results A
• 61 ratio of omega6 to omega3 Fatty Acid
  (Fish Oil) consumption was associated with a
  significantly increased risk of DES
• ConclusionsThese results suggest that a higher
  dietary intake of Omega3 Fatty Acids is
  associated with a decreased incidence of Dry Eye
  Syndrome in women
• Observations
• Added Omega 3 fish oil reduces and prevents dry
  eyes resulting from excess Omega-6 Plant oils in
  the diet
• Biljana Miljanovi , Komal A Trivedi, M Reza Dana,
  Jeffery P Gilbard, Julie E Buring and Debra A
  Schaumberg Brigham and Womens Hospital,
  Massachusetts Eye and Ear Infirmary Harvard
  Medical School, Boston, MA

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Western Diet Contains Excessive Saturated and
Trans Fatty Acids and Fewer Omega3 PUFAs than
Omega6 PUFAs

• High dietary intakes of Saturated Fatty Acids and
  trans fatty acids increase the risk of Heart
  Disease by elevating blood total and LDL
  cholesterol
• Omega-3 fish oil PUFAs reduce the risk of CVD via
  many mechanisms, including reductions in
  ventricular arrhythmias, blood clotting, serum
  triacylglycerol concentrations, growth of
  atherosclerotic plaques, and blood pressure
• After 3.5 years of takings 850 mg omega3 fatty
  acids, /- vitamin E subjects with preexisting
  CVD reported
• 20 reduction in mortality
• 45 reduction in sudden death
• Preventing or ameliorating many inflammatory and
  autoimmune diseases
• No difference total or LDL cholesterol after a
  50-d trial on Low and High fat diets that had
  identical ratios of PUFAs to SFAs, n6 PUFAs to
  n3 PUFAs, and MUFAs to total fat
• Low- (22 energy)
• High- (39 energy)
• Fat quality is more important than fat quantity
  in regard to CVD risk

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Latex Chemical Sensitivity

• Exposure comes from inhaled auto tires
• Immune system becomes depressed when we eat
  foods laden with naturally occurring latex
• Fruits and Vegetables make latex bittering agent
  to prevent animal damage
• Latex is converted protein and carbohydrate when
  fruits and vegetable ripens on the plant
  naturally
• Latex is trapped in the plant when picked green
  to ship
• Latex becomes injury protein when treated with
  ethylene gas in ALL grocery warehouses, such as
  Whole Foods, Wild Oats, Kroger, Giant Eagle, etc
• Symptoms are stiffness, fatigue, aches, redness
  on chin, cheeks, ears, and forehead, burning
  eyes
• Dried, frozen or canned foods have less latex

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Nutrient Replacement List

• Omega 3 Fish Oil (1000 mg cap), 1-2 caps before
  meals and at bedtime
• Good Start 1000-2000 mg of combine EPA and DHA
  daily
•  
• High Potency B Complex (B-50 or B100), 1 tablet
  before meals
• Multivitamin (for age and gender), 1/2 tablet
  twice daily
•  
• Magnesium Oxide 250 mg tabs, 1 tab before meals
  and at bedtime
•  
• Calcium 500 mg with Vit D, 1 tablet up to three
  time daily
• Do not take calcium at same time as thyroid
  dose
•  
• Vitamin C 1000 mg, 1 tablet before meals
• Vitamin E 400 IU, 1 cap twice a day
• Cinnamon caps 500mg, 2 caps before meals and at
  bedtime for
• Cholesterol, metabolic syndrome, diabetes,
  weight control, fatigue

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Credible Resources and Information About
Supplements, Herbal Products, Their Safety and
Effectiveness

• http//efaeducation.nih.gov for immune omega
  balance in diet
• www.nih.gov for basic answers to supplements
• www.ajcn.org for nutritional frontiers
• www.nutritiondata.com/facts for individual food
  omega-36 facts
• www.jacn.com for nutrition policies
• www.nci.gov for cancer supplements
• http//lpi.oregonstate.edu/ for new science in
  Nutrients
• www.consumerlab.com Products / Nutrients reports
  (subscription)
• http//medicalcenter.osu.edu/patientcare/hospitals
  andservices/primarycare/im/?CFID228520CFTOKEN20
  456422 for updates and Classes on Integrative
  Medicine
• www.naturalstandard.com for evidence-base CAM
  (subscription)
• Free Trial Logon for NaturalStandard for October
  is October
• Password for October is tomorrow

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Chicken Breast Roasted

• Nutritional Facts for Chicken, 1 unit breast
• broilers / fryers, breast, meat and skin, cooked,
  roasted
• Total omega-3 fats (est) 63.8 mg
•   Total omega-6 fats (est) 818 mg
• Omega 63 ratio 131
• Total Fat 4.5 grams
• Saturated Fat 1.3 grams
• Fat Calories 607
• Carbohydrate Calories 127
• Protein Calories 120
• Carb 0.0, Fats 40.7, Protein 73.5
• Healthy Foods approach 63 ration of 21
• http//www.nutritiondata.com

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Peanuts

• Nutritional Facts for Peanuts,
• all types, dry-roasted, without salt, 1 cup
• Total omega-3 fats (est) 44 mg
•   Total omega-6 fats (est) 22,910 mg
• Omega 63 ratio 5201
• Total Fat 218 grams
• Saturated Fat 25.2 grams
• Fat Calories 607
• Carbohydrate Calories 127
• Protein Calories 120
• Carb 15, Fats 71, Protein 14
• Healthy Foods approach 63 ration of 21
• http//www.nutritiondata.com

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Potato Chips With Olestra

• Nutritional Facts for Potato Chips
• With without Olestra
• Total omega-3 fats (est) mg
•   Total omega-6 fats (est) 818 mg
• Omega 63 ratio 131
• Total Fat 4.5 grams
• Saturated Fat 1.3 grams
• Fat Calories 607
• Carbohydrate Calories 127
• Protein Calories 120
• Carb 0.0, Fats 40.7, Protein 73.5
• Healthy Foods approach 63 ration of 21
• http//www.nutritiondata.com

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Avocado, Pureed

• Nutritional Facts, 1 cup avocado pureed
•  Total omega-3 fats (est) 221 mg
•   Total omega-6 fats (est) 3,396 mg
• Omega 63 ratio 151
• Total Fat 29.5 grams
• Saturated Fat 4.3 grams
• Fat Calories 247
• Carbohydrate Calories 61.5
• Protein Calories 13.5
• Carb 6, Fats 45, Protein 8
• Healthy Foods approach 63 ration of 21
• http//www.nutritiondata.com

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Food Choices to Balance Omega 36
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Just the Beginning of Opportunities
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Ayurveda Roles of InflammationNuclear
Factor-kappa B CURCUMIN (Turmeric Curcuma
longa) Ashwagandha (Withania somnifera)

• Slides From Hari Sharma, MD
• Ayurveda Practitioner
• The Ohio State University
• Center for Integrative Medicine

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CURCUMIN (Turmeric Curcuma longa)

• Prevents breast cancer spread in mice xenograft
  model.
• Interferes with proliferation of skin melanoma
  cells.
• Sensitizes cells to radiation and chemotherapy.
• Suppresses proliferation of wide variety of tumor
  cells Down regulates
• Transcription factor.
• Expression of COX-2, LOX, cell surface adhesion
  molecules, protein kinase, etc.
• Anti-mutagenic effect.
• Suppresses nuclear factor kappa beta (regulates
  inflamm. immune response).
• Blocks estrogen-mimicking chemical.
• Anti-inflammatory Inhibits cyclooxygenase-2
  (COX-2), lipoxygenase (LOX), thromboxane,
  leukotrienes, interleukin-12, hyaluronidase.
• Potent antioxidant (prevents damage to DNA and
  genes).
• Promotes normal cell cycle.
• Inhibits angiogenesis.
• Anti-thrombotic.
• Hepatoprotective.

References
Clin Cancer Res 200511(20)7490-7498 Anticancer
Res 200323363-398 J Ethnopharmacol
199338(2-3)113-119 Indian J Med Res
197159(8)1289-1295 Blood 20031011053-1062 J
Cell Biochem 2003891-5 Mol Cancer Ther
2003295-103 Pharmacol Res 200347113-140 Antica
ncer Res 200121873-878 Oncogene
2004261599-1607
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ASHWAGANDHA (Withania somnifera)

• Anti-tumor and radiosensitizing properties
• Adaptogenic
• Rasayana General and Medhya
• Increases quality and quantity of Ojas
• Clears Ama from channels
• Immune-enhancer
• Anti-cancer
• Prevents angiogenesis

References

• Food and Chem Toxicol 2004422015-2020
• Indian J Expt Biol 199230169-172,
  199634927-932, 199331607-611
• Med Sci Res 198715515-516
• Cancer Lett 199595189-193
• Acta Oncol 19963595-100
• Angiogenesis 20047115-122
• J Ethnopharmacol 200175165-168

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