ESBL producing Pseudomonas aeruginosa resistant to CAZ, ATM, FEP, borderline resistant to PIP, susce

1
ESBL producing Pseudomonas aeruginosa resistant
to CAZ, ATM, FEP, borderline resistant to PIP,
susceptible to TIM and TZP. Note the synergy
between TIM and CAZ (key hole) and the modest
synergy between TZP and ATM.
2

• Plasmid mediated ESBL
• in Pseudomonas aeruginosa
• Group 2be (class A enzyme)
• Inhibited by clavulanate, tazobactam
• Hydrolyse ceftazidime, aztreonam
• Key hole seen with Timentin /ceftazidime
• Rare ESBL
• PER-1, VEB-1

3
The ESBL producing Pseudomonas aeruginosa is also
resistant to the aminoglycosides, gentamicin (CN
10), tobramicin (TOB 10), amikacin (AK 30) and
ciprofloxacin (CIP 2.5).