DORA (Database for Online Retrieval and Analysis) is a web-accessible medical and laboratory information management system (LIMS), through which clinical, microarray, SNP, and metabonomic information from PolyomX-consented patients is stored, retrieved, - PowerPoint PPT Presentation

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DORA (Database for Online Retrieval and Analysis) is a web-accessible medical and laboratory information management system (LIMS), through which clinical, microarray, SNP, and metabonomic information from PolyomX-consented patients is stored, retrieved,

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Title: DORA (Database for Online Retrieval and Analysis) is a web-accessible medical and laboratory information management system (LIMS), through which clinical, microarray, SNP, and metabonomic information from PolyomX-consented patients is stored, retrieved,


1
DORA (Database for Online Retrieval and Analysis)
is a web-accessible medical and laboratory
information management system (LIMS), through
which clinical, microarray, SNP, and metabonomic
information from PolyomX-consented patients is
stored, retrieved, managed, and analyzed. DORA
is designed for data warehousing and has a
flexible relational database architecture that
can be readily scaled up to accommodate clinical
data from new cancer types, or experimental data
from new laboratory assays. PolyomX currently
collects clinical and molecular data for four
cancer types breast, lung, ovarian, and gastric.
DORA facilitates the generation of a cancer
knowledge base and will help individualize cancer
treatment by allowing researchers to identify
patient-specific characteristics of a cancer
disease at the molecular level. DORA supports
translational research by providing quick
electronic access to patient information from the
clinical and molecular domains. For example,
class prediction analysis is performed using the
signal intensity of the microarray spots and the
values of a clinical factor that partitions a
group of patients into two classes. Database
queries retrieve this information and present it
to the statistical analysis software in the
appropriate format. Confidentiality of the
information collected in DORA is strictly
maintained. Access to DORA is password-protected
and confidential information is encoded before
being stored in the database. Access to the
confidential information and modification of data
is highly restricted. For security reasons, DORA
is currently available only in the Cross Cancer
Institute computer network. Tumor banking
information is managed through the Tumor Banking
Database, a self-contained module of DORA. Please
see the poster on the Tumor Banking Database for
details. PolyomX is supported by the Alberta
Cancer Foundation and the Alberta Cancer Board.
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