LongTerm Corneal Thickness Response to Overnight Orthokeratology Reshaping

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Long-Term Corneal Thickness Response to Overnight
Orthokeratology Reshaping
ASCRS 2007

• Iane Stillitano
• Cesar Lipener
• Paulo Schor
• Ana Luisa Hofling-Lima
• Department of Ophthalmology
• Federal University of Sao Paulo/Brazil
• UNIFESP/EPM

ianestilitano_at_oftalmo.epm.br
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Purpose

• to analyse long-term corneal thickness response
  to overnight ortho-k remodeling during 1 year
  follow-up.

No financial support No commercial interest
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Methods

• Study Design
• Prospective
• - Clinical Parameters
• 34 eyes ( 16 patients ) mean age
  36.65.5years old
• Baseline refractive error -2.380.71 D (
  range -3.63D to -1.00D )
• Ortho-k BE lens design Be Free

Boston XO, DK 145 x 10-11 (cm2/ s) (ml O2 / ml x
mmHg) (ISO/Fatt) Baush Lomb, Rochester, NY.

• Ultrassonic pachymetry and Optical Pachymetry
  (ORBSCAN)
• - Measurements
• Baseline , 1, 8, 30, 90, 180 and 365 nights
  post-ortho-k.
• - Statistical
• ANOVA, Bonferroni

Aproved by the Medical Research Ethics Comittee
of UNIFESP All patients signed the Informed
Consent
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Results
Plt0.001
Stability plot Mean thickness from US
pachymetry
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Results
Plt0.001
Stability plot Mean T-RMS values over time
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Conclusion

• Optical Pachymetry
• NASAL We found significant statistical
  difference of the mean nasal thickness between
  1,8,30,90, 180 and 365 nights post-ortho-k
  (plt0.001). The mean thickness at night 365 was
  bigger than the others nights. We also found
  significant difference of the mean change from
  baseline of nasal thickness between all nights
  evaluated (plt0.001).
• CENTRAL Significant statistical difference of
  the mean central cornea thickness measured
  between nights post-ortho-k (p0.003) The mean
  thickness at night 8 was bigger than at night 30.
  The change from baseline of central thickness
  showed statistical difference between nights
  (p0.011).
• TEMPORAL We found significant difference of the
  mean temporal thickness between nights evaluated
  (p0.0026). The mean thickness at night 90 and
  365 were bigger than at baseline, however, the
  change from baseline of temporal thickness did
  not show difference between 1,8,30,90,180 and 365
  nights post-ortho-k (p0.069).

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Conclusion

• Ultrassonic Pachymetry
• NASAL We observed increase in nasal thickness
  from 565 (baseline) to 586 (night 365), however
  this difference was not statistical significant.
  We did not found difference of the change from
  baseline of nasal thickness between nights
  post-ortho-k (p0.771).
• CENTRAL We found significant statistical
  difference of the mean central cornea thickness
  measured between nights post-ortho-k (plt0.001).
  The mean thickness the folowing nights
  post-ortho-k were lower than at baseline, but the
  change from baseline of central thickness did not
  show statistical difference between nights
  (p0.011).
• TEMPORAL We observed increse of temporal
  thickness post-ortho-k,however this difference
  was not signifficant (p0.496) and the change
  from baseline was not different (p0.803).

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Long-Term Thickness Response to Overnight
Orthokeratology Corneal Reshaping
ASCRS 2007

• Iane Stillitano, MD
• THANK YOU
• Department of Ophthalmology
• Federal University of Sao Paulo/Brazil
• UNIFESP/EPM

ianestilitano_at_oftalmo.epm.br