Transdermal Magnesium Chloride Treatment of Fluoroquinolone Side Effects

1
Transdermal Magnesium Chloride Treatment of
Fluoroquinolone Side Effects

• An ongoing emergency experiment
• George Eby and Karen Eby
• http//george-eby-research.com
• Austin, Texas

2
IntroductionFluoroquinolone (and Quinolone)
Effects

• Serious side effects are known but incidences are
  rarely reported in medical literature
• Yet, http//google.com - fluoroquinolone
  side effects yields 114,000 pages
• Side effects - both immediate and long delayed
  (1 year) symptom onset with potential for
  permanent injury with no known treatment
• Main side effects Tendon ruptures and
  fibromyalgia-like symptoms
• Binding to DNA is mediated by magnesium ions
• Concentrates in skin and can photosensitize skin
• Depletes magnesium
• More specifically to side effects Causes
  peripheral neuropathy, chronic pain, depression
  and other neuropsychiatric illnesses including
  insomnia, irritability, suicidal ideation,
  suicide, heart problems, skin problems
  (photosensitivity), Pseudomembranous colitis
  (bacterial infection of colon), Rhabdomyolysis,
  Stevens-Johnson syndrome, lowered seizure
  threshold, hypoglycemia, kidney stones and damage
  to all internal organs and outright death.

3
Methods and Procedures Role of Transdermal
Magnesium Chloride

• Magnesium chloride inactivatesfluoroquinolones
  (see warning label on package inserts)
• Topically applied to skin, 33 magnesium
  chloride should bind with and neutralize
  fluoroquinolones concentratedin skin and
  perhaps body.
• Rapidly replaces depleted magnesium systemically
  to levels perhaps not achievable with oral
  magnesium
• Magnesium is a neuronal calcium channel blocker,
  like Lyrica
• Magnesium has sedating properties and helps
  induce sleep

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Mental Illnesses associated with Increasingly
Severe Neuronal Magnesium Deficiency

• From http//george-eby-research.com/html/depres
  sion-anxiety.html a 180 page report on magnesium
  and depression containing a magnesium and
  fluoroquinolone toxicity discussion.

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Results Case History 1

• A 32-year old, 53 110 pound woman became toxic
  from prescribed 500 mg 2 t/d 10 days
  ciprofloxacin after several days treatment.
  Symptoms included (cold water felt like boiling
  water), extreme pain in overworked right arm,
  severe Achilles heel tendon pain, insomnia, pain
  in all joints and limbs, vision impairment,
  irritability and depression. Before and after
  intoxication, blood panel was normal and fever
  was not present.
• Topical treatment with 33 magnesium chloride
  morning and evenings over both legs rapidly
  induced 14 to 16 hour sleep each day. After 10
  days treatment with topical magnesium chloride,
  her symptoms ended, except for irritability and
  tendon pain.
• She remained neurologically symptom free for 5
  months but relapsed from severe
  social/physiological stress becoming very
  irritable, depressed with suicidal ideation, and
  full body, severe chronic pain.
• Retreatment with topical magnesium for 10 days
  chloride terminated all complaints including
  tendon pain and irritability.

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ResultsCase History 2

• A 51 year-old 5 6 140 pound woman (non
  perimenopausal and nonmenopausal) suffered from
  fibromyalgia-like symptoms including depression
  and full body chronic pain with tendon pain in
  all limbs (including toes and fingers) and vision
  impairment for 7 years after administration of
  ciprofloxacin during breast cancer surgery.
• Oral magnesium (500 mg / day) for two years
  slightly reduced symptomology, but did not
  eliminate them and did not improve sleep.
• Topical 33 magnesium chloride application
  (lower legs and arms) in evening rapidly and
  greatly improved sleep and terminated multi-year
  paresthesia (asleep feeling) in fingers.
• Topical application for _____ days, resulted in
  __________

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Conclusions / Hypotheses

• Magnesium is not only depleted during
  fluoroquinolone intoxication, but magnesium
  homeostasis is hypothesized to be permanently
  down regulated (genetically?) to a level
  sometimes inconsistent with good mental or
  physical health
• Fluoroquinolone side effects are hypothesized to
  be very common, and severe side effects are much
  more common than previously believed, perhaps due
  to magnesium malnutrition
• Stress psychological, physical, environmental,
  metabolic (including MSG and calcium) is
  hypothesized to trigger relapses
• Topical magnesium chloride or other parenteral
  means of administering magnesium to higher than
  normal (0.9 mMol) levels is hypothesized to be
  effective as treatment and prophylaxis for
  fluoroquinolone toxicity and should be
  investigated