Slight acidification is an essential requirement for osteoclast activation by RANK ligand

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Adult human finger bone
Key 1 articular cartilage 2
cortical bone 3 trabecular bone 4 marrow 5
tendon
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Sub-periosteal bone remodelling
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Osteoclast in resorption cavity
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Osteonal (Haversian) systems in human cortical
(finger) bone
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Osteocyte lacunae canaliculae in human cortical
(finger) bone