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The Prevalence and Impact of Rheumatoid Arthritis

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Physical joint deformity resulting in pain and loss of mobility. Joint replacement surgery ... eg, pain, fatigue, helplessness, psychological difficulties ... – PowerPoint PPT presentation

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Title: The Prevalence and Impact of Rheumatoid Arthritis


1
The Prevalence and Impact of Rheumatoid Arthritis

2
Prevalence of RA
  • Disease prevalence of 0.51.0
  • Femalemale ratio of 2.51
  • Most common incidence among those aged 4070
    years
  • Disease incidence increases with age

3
RA Has a Long-Term Medical Impact
  • Radiographic progression
  • gt50 of patients have evidence of radiographic
    progression within 2 years of disease onset
  • Severe functional decline
  • progression of functional decline appears
    greatest in the early stages of disease
  • declines in functional status are associated with
    increased costs
  • Physical joint deformity resulting in pain and
    loss of mobility
  • Joint replacement surgery
  • Premature mortality
  • patients with more favourable clinical status are
    at less risk than those with poor status

4
RA Is a Substantial Pharmacoeconomic Burden
  • Increased direct costs
  • eg, costs of inpatient and outpatient care
  • Increased indirect costs
  • eg, loss of income
  • Increased intangible costs
  • eg, pain, fatigue, helplessness, psychological
    difficulties

5
The Destructive Events of RA Occur Early
  • Joint-space narrowing and erosion are seen
  • in gt67 of patients within the first 2 years of
    disease
  • in gt72 of patients within the first 5 years of
    disease
  • Radiographic progression occurs early and
    continues at a constant rate throughout the
    patients life

6
Importance of Early Aggressive Treatment of RA
50 of patients have evidence of radiographic
damage within the first 2 years
Early
Disease onset
Premature death
Established
End stage
Critical window of opportunity
7
Radiographic Progression is Related to
Disability in RA
Inflammation Disability Radiographs
Severity (Arbitrary Units)
0
5
10
15
20
25
30
Duration of Disease (Years)
Kirwan J. J Rheumatol. 199926720-725.
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