SURVEY ON THE QUALITY OF THE STEM CELLS DELIVERED FOR A BONE MARROW TRANSPLANTATION

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SURVEY ON THE QUALITY OF THE STEM CELLS
DELIVEREDFOR A BONE MARROW TRANSPLANTATION

• M-L.APPERT(1) , D.REA(2), C.RAFFOUX (1)
• (1) France Greffe de Moelle, Paris, France
• (2) Saint Louis Hospital, Paris, France
• With the participation of Pat Coppo, Sally
  Gordon, Susanne Morsch, Anna Chiu, Simona
  Pollichieni, Sinead Horgan.

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Goals of this Study

• Comparison of TNC (and if enough data CD34)
  quantities
• - requested by the grafted physician,
• - harvested at the collection center.
• - received at the transplant center.

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What do we mean by requested, harvested and
received quantity of NC ?
TRANSPLANT CENTER At the recruitment stage, the
transplant center indicates the requested
quantity of NC
COLLECTION CENTER At the harvest stage, the
harvest physician indicates the quantity of
harvested NC
CELL THERAPY LAB of the TRANSPLANT CENTER At
reception of the HSC product, a quality control
form is completed, with the quantity of NC
finally received
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WMDA Minneapolis - Nov 2005
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Recall of preceding results
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COLLECTIONS CHARACTERISTICS Requested
harvested quantities (. 108 CNT)
REAL QUANTITIES
REQUESTED Average 204.108CNT 95 CI 194
215 Median 200.108CNT Min 28.108CNT Max
860 .108CNT HARVESTED Average 212.108CNT 95
CI 203 222 Median 210.108CNT Min
27.108CNT Max 515 .108CNT
P(Wilcoxon test for paired samples) lt 0.01
-gt the difference is significant
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QUANTITIES/KG
COLLECTIONS CHARACTERISTICS Requested
harvested quantities(.108 CNT / patient kg)
REQUESTED / kg Average 3.7 95 CI 3.5
4.0 Median 3.6 Min 0.5 Max 16.5 HARVESTED
/ kg Average 4.1 95 CI 3.8 4.3 Median
3.5 Min 0.5 Max 18
P(Wilcoxon test for paired samples) lt 0.01
-gt the difference is significant