CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ECOLE SUPERIEURE DE BIOTECHNOLOGIE DE STRASBOURG UNIVER

1
Poly(ADP-ribosyl)ation of histones
Poly(ADP-ribosyl)ation of histone tails a
molecular link between DNA damageand chromatin
modification
Poly(ADP-ribosyl)ation of histone H1 induces
chromatin superstructure relaxation
32P NAD
Coomassie Blue
H1
E2
E14
E116
K213
40
H1-pADPR
H2B
E2
31
102
125
Histone code damaged chromatin
Recruitment of cell cycle checkpoints
proteins and DNA repair factors
a
c
b
control
NAD
PARG
Poirier G. et al. (1982) PNAS 79, 3423 - 3427