N SINGLE CHAIN AMPHIPHILES ? ? MICELLE

1

1. LIPID STRUCTURE A INTERMOLECULAR
   AGGREGATESMICELLE FORMATION THROUGH
   INTERMOLECULAR FORCES

1. LIPID STRUCTURE FORM COMPLEX STRUCTURES FROM
   SIMPLE MOLECULE

N SINGLE CHAIN AMPHIPHILES ? ? MICELLE
2

1. LIPID STRUCTURE B INTERMOLECULAR
   AGGREGATESBILAYER FORMATION THROUGH
   INTERMOLECULAR FORCES

N DOUBLE CHAIN AMPHIPHILES ? ? BILAYER
3

1. PROTEIN STRUCTURE INTRAMOLECULAR FOLDING

PROTEIN FOLDING
UNFOLDED POLYPEPTIDE CHAIN ? ? FOLDED PROTEIN
Short peptide
Long protein
4

1. MACROMOLECULE STRUCTURE DNA AND CHO

CHO
DNA
5

1. MACROMOLECULE FUNCTION BINDING

M L ?? ML
Ligand binding
Ligand release
Protein
DNA
DNA/Protein Complex
6

1. MACROMOLECULE FUNCTIONBINDING AND TRANSPORT
   (PHYSICAL STEP)

FACILITATED DIFFUSION
R Lout ?? RL ? R Lin
Lout
Ligand binding
receptor
receptor
Ligand release
Lin
7

1. MACROMOLECULE FUNCTION BINDING AND KINETICS
   (CHEMICAL STEP)

ENZYME KINETICS
E S ?? ES ? E P
Substrate binding
Product release
8

1. MACROMOLEUCLE FUNCTION BINDING AND CHEMICAL
   TRANSFORMATION

9

1. MACROMOLEUCLE FUNCTION BINDING AND
   CATALYSISSIGNAL TRANSDUCTION

M L ?? ML
R Lout ?? RL ? R Lin
E S ?? ES ? E P
hormone
adenylate cyclase
receptor
out
in
bg
bg
a
a
a
GDP
GTP
GDP
GTP
cAMP
ATP
Ga
Adenylate cyclase (cat. Domain)
PKAin
PKAact
phosphorylates proteins