Diabetes

1
(No Transcript)
2
Cancer
Diabetes
Osteoarthritis
Heart disease
Sleep apnoea
Respiratory problems
Gallbladder disease
3
Gut hormones and appetite regulation

• Badman Flier, Science (2005)

gt2 decades of research by Professor Steve Bloom
at Imperial College London
4
Oxyntomodulin reduces body weight in overweight
subjects

• Participants
• healthy overweight subjects
• 18-55 years
• stable BMI 25-40kg/m2

5
Oxyntomodulin analogues

• Objectives
• Increased potency
• Increased duration of effect

• Leveraging close relationship between Imperial
  College Thiakis
• Novel compounds invented in academic laboratory
• Exclusively licensed to Thiakis via Imperial
  Innovations

6
Intranasal PYY3-36

• Proprietary formulation of PYY3-36 for
  intra-nasal delivery
• Thiakis has granted Nastech a freedom-to-operate
  sublicence under its PYY patent estate, limited
  to intra-nasal field
• Phase I studies demonstrated dose-related
  treatment effect with intra-nasal PYY3-36 and
  product to be well tolerated
• Long-term Phase 2 weight loss clinical trial
  planned
• Future milestones and royalties on end-sales due
  to Thiakis

7
Founders Management

• John Burt (CEO)
• DPhil (Molecular Biology)
• Management consultant (PwC) RD finance
  (Vernalis)
• Licensing corporate development (GSK Imperial
  Innovations)
• Steve Bloom (CSO)
• Head of Division, Investigative Sciences,
  Imperial College Faculty of Medicine
• Leading academic researcher in field of gut
  hormones and appetite regulation

8
How do we fund expensive drug development?

• Nastech license and seed investment provided
  initial capital
• Further licence receipts and support from
  Imperial Innovations
• 10 million venture round (August 2006)
• Novo A/S, Advent Venture Partners, Imperial
  College, Royal Society, NPI Ventures, Consensus
  Business Group, Esperante
• Research Development Grant (LDA)
• RD tax credits
• Smart business model

Dont raise 100 to be worth 50!
9
Alizyme 232m Nastech 299m Arena
821m Orexigen 475m Phynova 9m
A safe effective obesity therapy will be a
blockbuster
10
Treating obesity by mimicking physiology