Clinical Summary Slide Lipids and Inflammation in Heart Disease Prevention

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Clinical Summary SlideLipids and Inflammation in
Heart Disease Prevention

• Atherosclerosis timeline ? foam cells, fatty
  streak, intermediate atheroma, plaque, rupture
• Risk assessment tools helpful but can lack
  sensitivity, especially in moderate or high risk
  groups
• NCEP Goals now widely promulgated
• LDL more risk disease
• position paper)
• METABOLIC SYNDROME BP 135/85
  Fasting Glucose 110
• Waist circumference 40 men 35 women
  TG 150 HDL
• Metabolic syndrome associated with 2.4-3.4 RR of
  CVD mortality Finnish study
• Cholesteryl ester transfer protein (CETP)
  facilitates the exchange of cholesteryl esters
  from
• HDL to apoB-containing lipoproteins for TG and,
  thus, may play a key role in reverse
• cholesterol transport. Inhibition of CTEP may
  prove beneficial.
• HDL and LDL particle size may also prove a
  significant variable.
• Combining CTEP inhibitor with STATIN may
  potentially work to normalize fully spectrum of
• LDL, HDL, VLDL particles in CHD patients
• PREVENTION OF CHD
• Present diet/exercise, smoke (-) BMI 40 TG
• Future Lipoprotein A CRP