Carbonyl Chemistry

1
Carbonyl Chemistry

• Vollhardt Sections
• 17-1,17-2, 17-5 to 17-7
• 19-7, 20-1

2
Carbonyl Nomenclature
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Carbonyl Nomenclature
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5
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9
Grignard Reagents
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Organometallic Reactions with Ketones
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Organolithium Formation
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Grignard Reagents are water sensitive
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15
Carboxylic Acid Derivatives
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17
Addition-Elimination
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Acid-catalyzed Addition-Elimination
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Base-Catalyzed Addition-Elimination
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Competition in Carboxylic Acids
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Esterification of Carboxylic Acid
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Esterification with MeOH
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Loss of water gives ester product
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Neutral Addition-Elimination
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Acidity of Carboxylic Acid Derivatives
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Ketone Hydration
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Ketone Hydration with Acid and Base
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Hemiacetal Formation
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Condensation Reactions
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Cyanohydrin Formation
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Cyanohydrin Mechanism
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Acid-Catalyzed Esterification
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Loss of water gives Ester
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Succinimide Formation
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Lactam Formation
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Carboxylic Acid Reduction
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Reaction is selective