WP2 Study on the programmes in third countries and existing international cooperations

1
WP2Study on the programmes in third countries
and existing international cooperations

• Inventory of pathogenomics-related programmes
• Ina Keutmann
• Project Management Jülich

2
Results Task 2.1

• Who was included in the inquiry?
• Methodology
• Responses
• ERA-NET Partners/ Third Countries
• Results sorted by Categories of national funding
• Transnational Funding/ Cooperations
• Summary

3
Investigation in and outside Europe

• Inquiry through questionnaire sent via E-mail
• 10 ERA-NET partner countries
• 21 Third European countries
• 16 Third countries outside Europe

Questionnaire was sent to approx. 150 contacts
in approx. 40 countries (Feedback rate
8) (ministries, foundations, national
institutes, academies, EU contacts (Cordis))

• Additional Identification of programmes and
  contacts by
• internet research
• Collaboration of the International bureau, Bonn

4
Questionnaire was sent to ERA-NET Partners on
December 8th 04 Questionnaire concerning
(inter-)national programmes A1 General
Programme Information A2 History and Road Map of
the Programme A3 Programme / Project
statistics A4 Research Content The ERA-NET
Partners were kindly asked to send the completed
questionnaire back until February 5th 2005
Answers from 4 Countries are still missing
5
Returned Questionnaires
6
Countries included in this survey Programmes,
Projects or Grants identified

7
Categories of national funding

• (Genome-)Programmes that, among other topics,
  cover pathogenomic projects
• National programmes, with pathogenomic related
  programme parts and larger projects that are part
  of a more general funding programme
• 3. Grants and Funds that cover pathogenomics
  related projects

8
Results
(Genome-)Programmes that, among other topics,
cover pathogenomic projects and larger projects
as part of a more general funding programme
e.g. Canada
1. Genome Canada 2. Genomics of Human
Pathogens and their Host Interactions 3.
Immunochemistry Program
9
Genome Canada

• Established by the federal government in April
  2000
• A not-for-profit corporation leading a national
  strategy on genomics and proteomics with 375 Mio
  in funding from the Government of Canada
• Dedicated to developing and implementing a
  national strategy in genomics and proteomics
  research
• Genome Canada has established 5 Genome Centres
  across the country
• 2 running programmes focused on human pathogens

10
Genome CanadaProjects

• 1. Comparative and Functional Genomics of the
  Human Pathogen Cryptococcus neoformans  
• Funding Genome Canada (50)
• Genome British Columbia (50)
• Funding Envelope total value 2.158.557 (
  1.322.040)
• Project goal to identify the virulence
  mechanisms by which Cryptococcus causes
  disease in humans

11
Genome CanadaProjects

• Genome wide Essential Gene Identification in
• Candida albicans and Applications to Antifungal
  Drug Discovery  
• Funding Genome Canada (50)
• Genome Québec (50)
• Funding Envelope Total value 5.740.927 (
  3.516.114)
• Project Goal to genetically dissect the
  organism
• to identify all essential genes
• to identify all drug targets

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2. Canadian Programme Genomics of Human
Pathogens and their Host Interactions The
programme is part of the Genomics and Health
Initiative (GHI)

• Funding Provided by the Canadian Federal
  Government through the National Research Council
  (NRC)
• Duration of the programme
• Original program (Genome Sciences in Infectious
  Diseases) 1999 to 2002
• renewed in 2002 as the Genomics of Human
  Pathogens and their Host Interactions continued
  until March 2005
• Funding Envelope Budget from 1999 to 2005 26
  Mio ( 15.924.077)
• Content The objective was to apply new genomics
  tools to three human pathogens, Candida albicans,
  Francisella tularensis and Campylobacter jejuni.
• 8 running projects focused on human pathogens

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3. Canadian Programme Immunochemistry Program

• Funding Organization Canadian federal Government
• Running since 1929, with changing of the current
  foci of the research
• Actually 2 running projects focused on human
  pathogens
• 1. Project Title Molecular Pathogenesis
• 2. Project Title Pathogen Genomics
• Details see report

14
(Genome-)Programmes that, among other topics,
cover pathogenomic projects and larger projects
as part of a more general funding programme

• e.g. USA
• Microbiology and Microbial Pathogenesis
  Programme
• Large Scale Genome Sequencing Program
• includes Pathogen Genomics

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1. USA ProgrammeMicrobiology and Microbial
Pathogenesis Programme
Programme Owner The National Institute for
Dental and Craniofacial Research (NIDCR)
(National Institute of Health, Department of
Health and Human Services) Sequencing support
since 1995 Funding Envelope The goal is a
success rate of 25 (by the end of the fiscal
year NIDCR will have funded 25 of the research
grant applications assigned to the
institute) Actually 13 running sequencing
projects focused on human pathogens
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2. USA Programme Pathogen Genomics within the
Large Scale Genome Sequencing Program

• Programme Owner
• National Institute of Allergy and Infectious
  Diseases NIAID/
• National Institute of Dental and Craniofacial
  Diseases NIDCR
• Running since September 1999
• An Addendum to this programme has been released
  in 2000 by the NIAID together with the Defence
  Advance Research Project Agency.
• This addendum complemented the Large Scale
  Genome Sequencing Program by focussing on
  pathogens as pathogen agents for bioterrorism.
• 40 running sequencing projects focused on human
  pathogens
• estimated 10 additional projects in the field of
  pathogenomics
• No detailed information was available in
  concerning the funding envelope

17
National programmes, with pathogenomic related
programme parts and larger projects that are part
of a more general funding programme e.g.

• Australia Medical Bioinformatics, Genomics and
  Proteomics Programme
• China Gene Manipulation Programme
• Germany Infection and Inflammation Network
• Japan National BioResource Project Pathogenic
  Microorganisms
• Research for the Future Programme
• Korea 21st Century RD Programme
• Malta National RTDI Programme
• Romania VIASAN National programme of
  Biomedical research
• Sweden Functional analysis of the vag-gen
  family-a constitute of conserved genes among
  bacterial pathogens
• Switzerland Antibiotic Resistance
• Taiwan National Research Programme for Genomic
  Medicine
• UK Plant and Microbial Science Programme/
  Agri-Food Programme
• Vietnam National Programme on Biotechnology

18
GermanyInfection and Inflammation Network of the
National Genome Research Network

• Programme Owner German Federal Ministry for
  Education and Research
• First Phase started 2001, actual programme runs
  from 2004 to 2007
• Funding 15.991.668 for the whole network
• 6.539.584 (14 microbial pathogens projects)
• Content The Infection and Inflammation Network
  of the NGFN has assembled scientific and
  clinical investigators of different backgrounds
  and comprises 9 work packages 3 WPs are
  concerned with human pathogenic bacteria
• WP 1 Sepsis WP 2 Gastrointestinal infections WP
  5 Tuberculosis
• The objective is to develop functional and
  comparative studies, into a molecular
  understanding of the human inflammatory response
  system in health and disease, thereby improving
  diagnostic and therapeutic options.
• 14 running projects focused on human pathogens
  (49 in total )

19
Switzerland Antibiotic resistance NRP49

• Programme Owner Swiss National Science
  Foundation
• Duration of the programme 19992006
• Funding Envelope CHF 12 million (7.763.473 )
  over a 5- year period
• Content - Scientific strategies of resistance
  monitoring
• - Survey of the current resistance situation
• - Determination of the degree of mobility of
  resistant bacteria and genes
• - Molecular studies on bacterial resistance
• - Social, legal, ethical and economic aspects
• 5-10 running projects focused on human
  pathogens (21 total)

20
RomaniaThe National Programme of Bio-medical
research and Development Life and Health
(VIASAN)

• Programme Owner The Ministry of Education and
  Research (MEdC)
• Running from 2001-2006
• Funding Envelope About 2,7 million for the
  projects in the Genomics and Proteomics field,
  including both clinical and fundamental research
• Content The VIASAN Programme includes four
  thematic fields of research Immunology Organ
  Transplant, Neuroscience, Cellular and Molecular
  Medicine and Genomics and Proteomics.
• 63 running projects for Genomics and Proteomics
  field

21
Grants and Funds that cover pathogenomics
related projects e.g.

• Ireland Science Foundation Ireland grants
• Israel Israel Scientific Foundation grants
• U.K. The Wellcome Trust
• New Zeeland Marsden Fund grants

22
United Kingdom

• Funding Organization The Wellcome Trust (WT)
• 1. 1995 Set up of the Pathogen Sequencing Unit
  (PSU) to sequence the genomes of organisms
  relevant to human and animal health
• PSU is now funded through the Sanger Institute
• Main budget provided by the WT
• Funding support of the Institute 300 Mio (432
  Mio ) from 2001 to 2006

23
United Kingdom

• Funding Organization The Wellcome Trust (WT)
• 2. Ad hoc applications are accepted in all areas
  of pathogen research
• e.g.
• Project grants
• 3 year-project grant awards 150 000 to 300.000
  (218.277 - 436.554 )
• Programme grants
• 5 year programme grant awards up to 1 200. 000
  (1.746.217 )

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Transnational Funding

• Europe
• Only one binational programme
• MICMAN
• Partner countries Finland Sweden
• Organizations Acadamy of Finland
• Swedish Foundation for Strategic Research
  (SSF)
• Duration of the programme 01.01.2003
  31.12.2005
• Main objective -to increase the understanding
  and knowledge of the interaction between
  host and microbes
• - to apply this knowledge to the maintenance
  of health
• and to prevention and treatment of diseases

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MICMAN

• Funding Envelope (1/2003 12/2005)
• The total budget of the programme 5,4 Mio
• Academy of Finland 4,1 Mio
• Swedish Foundation for Strategic Research 1,3
  Mio
• 15 research projects or consortia
• 5 Finnish-Swedish consortia
• 2 Finnish consortia
• 8 individual Finnish projects.
• Altogether 26 research groups are funded in these
  projects/consortia

26
Transnational FundingSpecial Programme for
Research and Training in Tropical Diseases (TDR)
Global Collaborative research grant
Pathogenesis and Applied Genomics TDR is an
independent global programme of scientific
collaboration co-sponsored by United Nations
Children's Fund (UNICEF) United Nations
Development Programme (UNDP) World Bank World
Health Organization (WHO) TDR depends on
voluntary contributions from donors for most of
its income.   In 2004, contributing partners
consisted of 4 co-sponsors 23 governments 9
other (foundations, agencies etc.) Total Budget
for 2004 US 6.614.992,00 (5.122.738 )
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Special Programme for Research and Training in
Tropical Diseases (TDR)Pathogenesis and Applied
Genomics

• Duration Established in 1975
• The aim is to help coordinate, support and
  influence global efforts to combat a portfolio of
  major diseases of the poor and disadvantaged
• TDR supported international efforts to unravel
  the genomes of tropical parasites through five
  genome networks.
• Funding
• Research projects up to US 35 000 per year for
  2 years
• one-time renewal possible (27.105 )
• Multicentre projects up to a total of US 70
  000 per annum and for a 2 years (54.210 )
• The project must involve endemic country
  researchers (South-South or South-North
  collaborations)

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Transnational Cooperations European results

• Finland/ MICMAN
• Sweden
• Norway The national functional genomics
  research programme in Norway (FUGE)
• Cooperation with Norwegian and foreign research
  groups
• Ireland The Health Research Board works closely
  with partners in Northern Ireland, the United
  States and Europe
• .

29
Transnational CooperationsResults Outside Europe

• Canada Genomics of Human Pathogens and their
  Host Interactions
• formal collaborations with institutes and
  research groups in Europe and USA. The GHI
  Coordination Office considered this information
  confidential.
• - Immunochemistry Program
• international research collaborations are too
  numerous to list.
• Israel German Israel foundation for Scientific
  Research and Development
• US Israel binational Science fund (BSF)
• Korea The 21st Century Frontier RD Program
  includes foreign collaboration due to the problem
  of the shortage of home-grown talents
• Vietnam National Program on Biotechnology
• Cooperations with Japan, UK, Australia, Germany

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USA International Collaborations in Infectious
Disease Research ProgramProjects in Cooperation
with Universities of
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Summary

• Pathogenomic related projects covered by
  unspecific programmes
• Obviously most focused countries outside Europe
  Canada and USA
• Transnational pathogenomic activities on
  programme level are rare
• In Europe only Finland and Sweden
• Most mentioned scientific contents have been
  questions on
• The host pathogen interaction
• The problem of resistance
• Genome sequencing for further applications

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Summary

• Pathogenomic related projects covered by
  unspecific programmes
• Obviously most focused countries outside Europe
  Canada and USA
• Transnational pathogenomic activities on
  programme level are rare
• In Europe only Finland and Sweden
• Most mentioned scientific contents have been
  questions on
• The host pathogen interaction
• The problem of resistance
• Genome sequencing for further applications
• There is a big need for coordination
  activities!

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• Thank you for your kind attention!
• Any Questions!

35

• Some Coffee or thee after the dry sheets?

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JapanNational BioRsource Project "Pathogenic
Microorganisms (Bacteria, Fungi and Protozoa)
Part of the "Research Revolution 2002 (RR2002)

• Programme Owner Japanese Ministry of Education,
  Culture, Sports, Science and Technology (MEXT)
• Running from 2003-2008
• No information on funding budget available
• Content - research in infections and
  microorganisms
• - education of students in the control of
  infections
• - basic research for countermeasures against
  bioterrorism
• - providing of a systematic accumulation,
  storage and provision structure for nationally
  recognized bio resources
• 24 central resource centres and an
  information centre are involved