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Opium Analgesics

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... bringing poppy' Many varieties, colors. Poppy seed. Latex from pod. Tincture. Smoked. Opium. Oldest drug. History. Mixture of alkaloids. Morphine. Morphine ... – PowerPoint PPT presentation

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Title: Opium Analgesics


1
Opium Analgesics
  • Chapter 21

2
Opiates
  • Analgesic properties
  • Problem?
  • Why opiates?
  • What are opiates?

3
Poppy
  • Papaver somniferum
  • Sleep-bringing poppy
  • Many varieties, colors
  • Poppy seed
  • Latex from pod
  • Tincture
  • Smoked

4
Opium
  • Oldest drug
  • History
  • Mixture of alkaloids
  • Morphine

5
Morphine
  • Timeline
  • 1803 isolated
  • 1833 purified
  • 1853 medicine
  • 1881 functional groups identified
  • 1925 structure proposed
  • 1953 synthesis
  • 1968 structure confirmed
  • Properties
  • Structure
  • Stereochemistry

6
Structure-activityrelationships
  • Phenolic OH
  • Other alcohol
  • Double bond
  • N-methyl group
  • Aromatic ring
  • Ether bridge

7
Development of morphine analogs
  • Remember this pharmacophore example?

8
Development of morphine analogs
  • Vary substituents

9
Development of morphine analogs
  • Vary substituents
  • Extension of drug

10
Development of morphine analogs
  • Vary substituents
  • Extension of drug
  • Simplification of structure

11
Development of morphine analogs
  • Vary substituents
  • Extension of drug
  • Simplification of structure
  • Rigidification

12
Receptor theory
  • m receptor
  • k receptor
  • d receptor

13
A question.
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