Cytokine application - PowerPoint PPT Presentation

1 / 23
About This Presentation
Title:

Cytokine application

Description:

Three years ago he had appendicitis and received ... Ret. Reference. http://www.geocities.com/ilir_status/ ????? ????????????? : ?????????????? ???? 1 , ... – PowerPoint PPT presentation

Number of Views:63
Avg rating:3.0/5.0
Slides: 24
Provided by: amsC4
Category:

less

Transcript and Presenter's Notes

Title: Cytokine application


1
Are you ready ?
Let ' s go....
2
Cytokine application
Advisor Prasit Chanarat
  • By Amporn Leejarendkeat
  • Arnon Phanpha
  • Phinitra Chanthubthong

3
Case study of Ilir Kullolli
4
Ilir Kullolli
  • A Foreign exchange student from Albania
  • Three years ago he had appendicitis and received
    Chloramphenecol for treatment
  • He was hospitalized with some illness on
    November 1999

5
Clinical Signs Symptoms
  • - Decline in energy
  • - Nosebleeds
  • - Bleeding gums
  • - Bruises
  • - Blood in urine
  • - Extremely lowered platelet count

6
Laboratory
- CBC Hb 6 g/dl Hct 16 - WBC
count 1,000 cells/cu.mm - Platelet count
29,000 cells/cu.mm - RBC count 1,000,000
cells/cu.mm
7
Diagnosis
  • Aplastic anemia
  • Caused by side effect of chloramphenecol
    when treated appendicitis

8
History of Ilirs Treatment
?? 1999- Platelet given Increased level of
platelet count - ATG (Anti-Thymocyte Globulin )
Reduced T-lymphocytes - Cyclosporin
Magnesium (IV) Inhibit activity of
T-lymphocyte
9
?? 2000 - Platelet given - Cyclosporin
Magnesium - G-CSF (shot given in arm)
Boost white blood cell count - EPO (shot
given in arm) Boost red blood cell
count
10
After treatment
July 5, 2001 Finally some blood checks...
here are the results Platelets 170,000
cells/cu.mm White blood cells 4,500
cells/cu.mm Red blood cells
4,450,000 cells/cu.mm Hct 47.4
Hb 14.8 g/dl Everything
looks normal and Ilir is leading a very normal
life
11
(No Transcript)
12
(No Transcript)
13
(No Transcript)
14
(No Transcript)
15
(No Transcript)
16
Cytokine
  • Protein ???? Glycoprotein
  • ???????? lymphocyte , monocyte , macrophage
    ????????????????
  • ????????????????????????????? specific receptor

17
Role of cytokine
- Proliferation ?????????? cell
???????????????? - Differentiation
??????????????????? cell - Activation of mature
cell ???????????????? cell - Maintain
survival ??????? cell ??????????????
18
(No Transcript)
19
Granulocyte colony stimulating factor (
G-CSF )
  • Growth factors ???? Cytokine
  • ???????? monocyte , endothelial cell
  • ???????????? gene ?? chromosome ?????? 17
  • ??????????????? granolocytic cells
    (neutrophil)

20
Biological action
CFU - GEMM
multi - CSF
GM - CSF
CFU - GM
CFU - G
G - CSF
GM - CSF ,IL - 3
Neutrophils
21
Erythropoietin ( EPO )
  • Glycoprotein growth factor
  • ???????? cell ??????????????????? proximal
    renal tubules
  • ????????????? RBC

22
Biological action
23
Reference
  • http//www.geocities.com/ilir_status/
  • ????? ????????????? ?????????????? ???? 1
    , ???? 18 - 31
  • ???? ??????????? ????????????????????????
    , ???? 440 - 447
Write a Comment
User Comments (0)
About PowerShow.com