myGrid -putting the scientist at the centre

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myGrid -putting the scientist at the centre

• A case study investigating Williams-Beuren
  Syndrome

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The scientists (Hannahs) problem
Physical Map
CTA-315H11
CTB-51J22
Gap
1.5 Mb

• Identify new, overlapping sequence of interest
• Characterise the new sequence at nucleotide and
  amino acid level

7q11.23
Cutting and pasting between numerous web-based
services i.e. BLAST, InterProScan etc
Chr 7 155 Mb
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The Williams Workflows
A
B
C
A Identification of overlapping sequence B
Characterisation of nucleotide sequence C
Characterisation of protein sequence
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Recording Architecture
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The myGrid Information Model Annotation
argumentation
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Using workflows and web services

• Automation
• Capturing processes in an explicit manner
• Tedium! Computers dont get bored/distracted/hungr
  y/impatient!
• Saves repeated time and effort
• Modification, maintenance, substitution and
  personalisation
• Easy to share, explain, relocate, reuse and build
• Available to wider audience dont need to be a
  coder, just need to know how to do Bioinformatics
  
• Releases Scientists/Bioinformaticians to do other
  work
• Record
• Provenance what the data is like, where it came
  from, its quality
• Management of data (LSID - Life Science
  IDentifiers)

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Demonstration topics

• Taverna using a workflow editing environment to
  capture bioinformatics protocols
• Personalisation setting context to allow later
  personalisation
• Provenance retaining information on the origin
  of results

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The myGrid Information Model Programmes, studies
experiments
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The myGrid Information Model Provenance metadata