Absorption, Distribution - PowerPoint PPT Presentation

1 / 16
About This Presentation
Title:

Absorption, Distribution

Description:

Absorption, Distribution & Biotransformation. Absorption ... Biliary excretion. Lungs, skin, sweat, milk. Kidneys. M.W. Effect of Bile Duct Ligation/Blockage ... – PowerPoint PPT presentation

Number of Views:66
Avg rating:3.0/5.0
Slides: 17
Provided by: linsu3
Category:

less

Transcript and Presenter's Notes

Title: Absorption, Distribution


1
  • Absorption, Distribution Biotransformation
  • Absorption Distribution
  • Anatomy of Cell Membrane (solubility, ionization)
  • Absorption (GI tract, lungs, skin)
  • Distribution
  • Plasma-protein transport
  • Blood-brain barrier
  • Storage
  • Tissue-plasma equilibrium

2
Local effects vs Systemic effects
Requires absorption Where?? How??
3
Anatomy of Cell Membrane
a. Protein channels b. Phospholipid
bilayer Selectively permeable
  • Polarity/solubility
  • pH an Ionization
  • Carboxylic acid
  • Strychnine
  • 2,4,D
  • Concentration Depnt.
  • Carrier-mediated transport

4
Quiz Which chemicals are most water soluble?
Which are least water soluble? Why?
5
Ionization
Carboxylic acid (COOH) Strychnine 2,4 D
(herbicide)
6
Ionization and Diffusion Across a Membrane
Stomach (pH 2.0)
Blood (pH 7.2)
7
Ionization and Diffusion Stomach vs Intestine
Stomach
Weak acid
Note magnitude of equilibrium arrows
Weak base
Intestine
Weak acid
Weak base
8
  • Respiratory absorption
  • Lung surface area 100 m2
  • Dermal absorption

9
Distribution
1. Plasma transport (non-covalent, covalent
binding to proteins
Non-polar
Polar
Non-Polar
Polar
10
  • 2. Blood-brain barrier placental barrier
  • 3. Storage
  • Kidney liver (metallothioneins)
  • Fat (eg. PCBs)
  • Bone (eg. lead, fluoride)
  • Hair, fingernails (eg. arsenic)
  • 4. Tissue-plasma equilibrium

11
Excretion
  • Kidneys (most small MW, polar)
  • Gall bladder (larger MW polar conjugates)
  • Faeces
  • Biliary excretion
  • Lungs, skin, sweat, milk

12
M.W.
Kidneys
13
Effect of Bile Duct Ligation/Blockage
14
(No Transcript)
15
(No Transcript)
16
(No Transcript)
Write a Comment
User Comments (0)
About PowerShow.com