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LIFE CYCLES OF VIRUSES

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SOME VIRUSES EXHIBIT ONLY THE LYTIC CYLE. ... HOW ANIMAL VIRUSES ENTER ANIMAL CELLS ... CREUTZFELDT - JAKOB DISEASE (CJD) KURU ... – PowerPoint PPT presentation

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Title: LIFE CYCLES OF VIRUSES


1
LIFE CYCLES OF VIRUSES
2
  • VIRUSES CAN EXHIBIT TWO TYPES OF LIFE CYCLES.
  • 1. THE LYTIC CYCLE
  • 2. THE LYSOGENIC CYCLE
  • SOME VIRUSES EXHIBIT ONLY THE LYTIC CYLE.
  • SOME VIRUSES CAN EXHIBIT BOTH LYTIC AND LYSOGENIC
    CYCLES.

3
THE LYTIC CYCLE
4
(No Transcript)
5
ONE-STEP GROWTH CURVE
6
THE LYSOGENIC CYCLE
7
HOW ANIMAL VIRUSES ENTER ANIMAL CELLS
8
(No Transcript)
9
(No Transcript)
10
  • VARIETY OF ANIMAL VIRAL INFECTIONS - LYTIC OR
    LYSOGENIC VIRUSES?

11
TRANSDUCTION
12
HOW ARE ANIMAL VIRUSES CULTURED IN THE LABORATORY
  • CLASSIFICATION OF MEDIA
  • LIVING MEDIA AND NON-LIVING MEDIA

13
CELL CULTURE
14
(No Transcript)
15
HOW ARE CELL CULTURES GROWN?
16
  • CYTOPATHIC EFFECT - CPE
  • SOME VIRUSES, WHEN THEY INFECT A CELL, CHANGE THE
    MORPHOLOGY OF THE CELL IN VERY SPECIFIC WAYS.

17
ANTIVIRAL AGENTS
  • GENERALIZATIONS
  • AMANTADINE
  • A VARIETY OF NUCLEOSIDE ANALOGS
  • ACYCLOVIR, AZT, 3TC, DDI, DDC
  • PROTEASE INHIBITORS
  • INTERFERONS

18
AMANTADINE
19
AVARIETY OF NUCLEOSIDE ANALOGS
20
PROTEASE INHIBITORS AND INTERFERONS
21
(No Transcript)
22
HEPATITIS VIRUSES
  • HAV 50
  • HBV 30
  • HCV 20
  • MODE OF TRANSMISSION
  • CHRONICITY - CHRONIC OR ACUTE INFECTION
  • TREATMENT/VACCINE

23
UNCONVENTIONAL INFECTIVE AGENTS
  • VIROIDS - 1967
  • SMALL CIRCULAR MOLECULES OF SINGLE STRANDED RNA
  • BEST STUDIED VIROID CAUSES DISEASE IN POTATOES
  • COMPOSED OF 359 NUCLEOTIDES
  • 10X SMALLER THAN SMALLEST KNOWN VIRUS

24
PRIONS
  • INFECTIOUS SELF REPLICATING PROTEINS
  • COMPOSED OF ABOUT 250 AMINO ACIDS
  • 100X SMALLER THAN THE SMALLEST KNOWN VIRUS
  • CAUSATIVE AGENT OF MAD COW DISEASE (BOVINE
    SPONGIFORM ENCEPHALOPATHY) AND TWO HUMAN DISEASES
  • CREUTZFELDT - JAKOB DISEASE (CJD)
  • KURU
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