Principles of Immunology The Inflammatory Process 4/6/06 - PowerPoint PPT Presentation

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Principles of Immunology The Inflammatory Process 4/6/06

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Cell Adhesion Molecules (CAMs) Required for extravasation. Neutrophil extravasation ... Ig CAMs. Expressed on endothelial cells. Bind to integrins. Margination ... – PowerPoint PPT presentation

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Title: Principles of Immunology The Inflammatory Process 4/6/06


1
Principles of ImmunologyThe Inflammatory
Process4/6/06
  • "Life is not measured by the number of breaths we
    take, but by those special moments that take our
    breath away." Anonymous

2
Word/Terms List
  • Acute phase proteins
  • Cell adhesion molecules
  • Chemotaxis
  • HEVs
  • ICAMs
  • Integrins
  • Mucins
  • Selectins

3
Inflammatory Process
  • A localized tissue response
  • Triggered by trauma and/or antigenic insult
  • May include systemic effects
  • Characterized by redness, heat, swelling, and
    pain
  • Principal cells are leukocytes and macrophages

4
Cell Adhesion Molecules (CAMs)
  • Required for extravasation
  • Neutrophil extravasation
  • Lymphocyte extravasation

5
Cell Adhesion Molecules (CAMs)
  • Selectins
  • Glycoproteins
  • Bind to carbohydrates
  • Expressed on leukocytes and endothelial cells
  • Mucins
  • Proteins
  • Present CHO ligands to selectins
  • Present on endothelial cells and neutrophils
  • Integrins
  • Proteins heterodimers
  • Expressed on leukocytes
  • Bind to Ig superfamily molecules
  • ICAMs
  • Ig CAMs
  • Expressed on endothelial cells
  • Bind to integrins

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7
Margination and Extravasation
  • Rolling
  • Activation
  • Arrest
  • Transendothelial migration

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10
Overview of Inflammation
  • Cells involved
  • Monocytes/macrophages
  • Neutrophils
  • Mediators
  • Histamine
  • Cytokines
  • Kinins
  • Vascular changes
  • Dilation
  • Increased permeability
  • Complement

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12
Effects of Macrophage Cytokines
  • IL-1, IL-6, TNF alpha
  • Pyrogenic
  • Vascular permeability
  • Expression of CAMs
  • T and B cell activation
  • Ig synthesis

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14
Systemic Changes
  • Fever
  • Acute phase proteins
  • Leukocytosis

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Interferon Effects
  • T Helper induction
  • Macrophage activation
  • MHC expression
  • NK cytotoxicity
  • B cell activation

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Lymphocyte Extravasation
  • Naïve lymphocytes
  • Occurs in secondary lymphoid organs
  • Occurs in high endothelial venules (HEVs)
  • Lymphocte homing

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