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Biodegradation of Xenobiotic Compounds Xenobiotics : compound have been produced artificially by chemical synthesis for industrial or agricultural purposes e.g ...
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METABOLISM OF XENOBIOTICS dr Agus Budiman Xenobiotics ( Xenos = strange) are compounds that are foreign to the body. It includes drugs, food additives, pollutants etc ...
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ENVR/TOXC 442 Fall 2012 Metabolism of Xenobiotics II. Phase 1 Metabolism Aug 23, 2012 L.M. Ball Rosenau 158 lmball@unc.edu Monoamine oxidase Metabolizes endogenous ...
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ENVR/TOXC 442 Fall 2011 Metabolism of Xenobiotics II. Phase 1 Metabolism Aug 30, 2011 L.M. Ball Rosenau 158 lmball@unc.edu Amidases Hydrolyse amides to carboxylic ...
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Hormonally Active Agents (HAA's) Human and animal ... (PCP's) Disinfectants, Deodorants, Fragrances, Flavoring agents, insect repellants, sunscreens. ...
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Metabolism of xenobiotics Vladim ra Kvasnicov XENOBIOTICS = compounds foreign to the body ENTRANCE TO THE BODY digestive tract blood LIVER lungs blood ...
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Chemical Carcinogens - aflatoxin. Environmental Pollutants - polychlorinated biphenyls (PCBs) ... Metabolism of Aflatoxin. Rapid Detoxication of Aflatoxiin Epoxide by ...
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ENVR/TOXC 442 Fall 2011 Metabolism of Xenobiotics I. General Overview Aug 25, 2011 L.M. Ball Rosenau 158 lmball@unc.edu Metabolism: Chemical reactions carried out by ...
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Chapter 3 Transportation and Transformation of Xenobiotics Toxicology-chapter 3 * Toxicology-chapter 3 * Phase I biotransformation Hydrolysis: functional group such ...
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Biotransformation of Xenobiotics Barbara M. Davit, PhD, DABT Division of Bioequivalence, Office of Generic Drugs, CDER, FDA Introduction to the Theory and
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Influence of route of administration on the clinical action of diazepam. Data from Assaf et al. Anaesthesia 30:152-158, 1975. 2 ...
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1.) fate of xenobiotic -- central role of metabolism. Uptake/Transport - Metabolism -Excretion ... 2.) xenobiotic converted by 2-step process ...
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VOLUME OF DISTRIBUTION FOR SOME DRUGS. DRUG Vd (L) cocaine 140. clonazepam 210. amitriptyline 1050. amiodarone ~5000. 5. What is the volume of water in ...
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Where do biotransformations occur? Liver is the principal organ of drug metabolism although every tissue has some ability to metabolize drugs.
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Wastewater, Pesticides, herbicides, petrochemicals and products (eg. ... used by oil industry to destroy oily wastes, also used for sludges from sewage ...
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Biological Methods 10.1-Basic Microbial Metabolism 10.2 Biodegradation of Xenobiotics Materials are taken from the Textbook: Hazardous Waste Management. 2nd Ed.
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ENVR/TOXC 442 Fall 2009 Metabolism of Xenobiotics II. Phase 1 Metabolism Sept 1, 2009 L.M. Ball Rosenau 158 lmball@unc.edu Changes in P450 levels with age Rats 2A1 ...
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ENVR/TOXC 442 Fall 2012 Metabolism of Xenobiotics II. Phase 1 Metabolism Aug 23, 2012 L.M. Ball Rosenau 158 lmball@unc.edu Monoamine oxidase Metabolizes endogenous ...
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defines where in the body a xenobiotic will go after absorption ... Assumes xenobiotic enters the first compartment. Assumes that xenobiotic is distributed to ...
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Change concentrations that are present to have effect ... Biodegradation requires the presence of the appropriate ... Very common way for xenobiotic to degrade ...
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Adoption studies separate genetic vs environmental factors ... Differential response to xenobiotic. aversion. reinforcement. Complex genetic trait by definition ...
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XENOBIOTIC METABOLISM ... Most importance enzyme in xenobiotic metabolism ... Activity of xenobiotic metabolizing enzymes can be vary between individual ...
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Xenobiotic. Membrane. Partitioning. Ion Gradient Interruption. Failed ATP Production ... Xenobiotic. Binding to cytoskeletal components -Redox cycling - SH ...
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Department of Molecular Environmental Epidemiology. National Institute of ... IMPORTANT ISSUES IN ... polymorphisms of xenobiotic-metabolising enzymes may ...
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An Introductory Lecture to Environmental Epidemiology Part 4. Some Issues in ... Interaction of xenobiotic substance and molecule. Measures of dose. Temporal issues: ...
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Importance of Drug Metabolism ... is a thiol-containing tripeptide of great significance in the detoxification and toxification of drugs and other xenobiotics.
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The Science behind Scenario Planning: Complex Systems ... Absorbing, buffering, diluting, detoxifying pollutants-xenobiotic. Ecosystem processes include ...
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Upon ligand binding, AhR heterodimerizes with its partner protein aryl ... encode for xenobiotic metabolizing enzymes, such as Xenobiotic Response Element ...
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... metabolism of a drug or other xenobiotic during the absorption process. Typically in the liver or gastrointestinal tract after oral administration. ...
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Metabolism of Bile Pigments and Jaundice ... (xenobiotics ...
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... capacity - The amount of a xenobiotic compound that can be metabolized by aerobic ... Nitrate reduction is an important pathway for xenobiotic compounds ...
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Manjishtha Capsules is a pure herbal product prepared by Planet Ayurveda that gives countless benefits. This is prepared with the pure extract of best quality Rubia cordifolia. According to the ancient Ayurvedic text, Bhava Prakash, Manjishtha is able to bind the free radical (amavisha) and xenobiotic (garavisha) toxins which cause inflammation (shotha), skin diseases (kushta), ulcers (vrana), among other problems. Manjishtha is widely used as a blood purifier. It acts mainly on rasa and rakta srotasas, alleviates the kapha and pitta doshas and eliminates toxins.
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Designing a QSAR. for ER Binding. QSAR. Xenobiotic. ER Binding. Altered. Protein. Expression ... Prioritize chemicals based on ability to bind ER (plausibly ...
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aspirin is a general COX-inhibitor(irreversible) morphine binds to an opiate receptor ... more than one type of xenobiotic may be needed for activation ...
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What is the poison The fate of poison in organism Application mode and bioavailability,metabolism Inhalation-Sniffing ... BIOTRANSFORMATION OF XENOBIOTICS ...
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Classify microorganisms according to their characteristics and metabolic processes. ... Xenobiotic chemicals - Chemicals not naturally found in the environment. ...
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Genomics Technology to Assessing Microbial Activity in the Environment ... 8 x 106 Xenobiotic. 1 x 106 Recalcitrant. 0.4 x 106 traded at over 50 tonnes per year ...
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What is toxicology? Modern Toxicology Exogeneous agents Endogenous compounds Oxygen radical Reactive intermediates generated from xenobiotics and endobiotics ...
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Effect of Estradiol 17 beta-D glucuronide, Rifampicin and a new ... GS-Xenobiotic. Bilirubin. Mrp 2. OATP. B-UGT 1. Glu-Bilirubin. CYTOKINES. PgP. SEPSIS. eff: ...
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Industrial wastewaters can, in general, be effectively treated using anaerobic ... tetrachloride etc.), xenobiotic products and side products (insecticides, ...
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?a???s ?a ? ??a pe?? ?????t??, 5 ??????? 2006. 2 ... 'The term xenobiotic was coined to cover all organic compounds that were foreign ...
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Oral Clefts, Environmental Exposures, and. Genetic Variation of Candidate Genes ... Xenobiotic metabolizing enzymes. phase 1 : CYP2D6, NAT1, NAT2, EPHX1 ...
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Insecticide aquatic ecotoxicity Insects are arthropods (Class Insecta). Many Arthropods share similar neurochemical or xenobiotic metabolism pathways.
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Interindividual Variation in Trough Concentrations of SQV, IDV, and NFV ... Protease Inhibitor Activation of the Xenobiotic Receptors. PXR. Repressor. PI. Transporters ...
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Toxicology 3. toxicokinetics Biotransformation: Hepatic-first pass metabolism Xenobiotics absorbed from the gastrointestinal tract Exceptions: Mouth (Nitroglycerine,
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COST 636 Xenobiotics in the Urban Water Cycle Kick-off meeting ... xenobiotic organic compounds. heavy metals. strong urban source. input FROM urban areas WG1 ...
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Oxidative stress is imposed on cells as a result of one of three factors: 1) an ... P450 metabolism of xenobiotic compounds, stimulation of phagocytosis by ...
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Biosynthesis of Macromolecules Anabolism - use energy (ATP) from catabolism - use carbon from sugars, lipids, proteins, or any other carbon source (xenobiotics) to ...
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Environmental Health and Toxicology Chapter 3 Metabolism of Xenobiotics (foreign compounds) Precarcinogens Vinyl chloride Starting ...
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